2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
反应条件
1: sodium hydride
2: diisobutylaluminium hydride
View Scheme
参考文献
Nakagawa-Goto, Kyoko; Crimmins, Michael T.
Synthetic Communications, 2011 , vol. 41, # 20 p. 3032 - 3038
反应条件
1: 1.) NaH / 1.) DMF, room temperature, overnight, 2.) 12 h
2: 80.5 percent / pyridinium dichromate / CH2Cl2 / 96 h
3: 93 percent / NaH / dimethylsulfoxide / Ambient temperature
View Scheme
参考文献
Ackroyd; Manro; Scheinmann; et al.
Tetrahedron Letters, 1983 , vol. 24, # 46 p. 5139 - 5140
反应条件
1: 1.) NaH / 1.) DMF, room temperature, overnight, 2.) 12 h
2: 80.5 percent / pyridinium dichromate / CH2Cl2 / 96 h
3: 93 percent / NaH / dimethylsulfoxide / Ambient temperature
4: Na, NH3 liquid
View Scheme
参考文献
Ackroyd; Manro; Scheinmann; et al.
Tetrahedron Letters, 1983 , vol. 24, # 46 p. 5139 - 5140
反应条件
1: 1.) NaH / 1.) DMF, room temperature, overnight, 2.) 12 h
2: 80.5 percent / pyridinium dichromate / CH2Cl2 / 96 h
3: 93 percent / NaH / dimethylsulfoxide / Ambient temperature
4: Na, NH3 liquid
5: diethyl ether
View Scheme
参考文献
Ackroyd; Manro; Scheinmann; et al.
Tetrahedron Letters, 1983 , vol. 24, # 46 p. 5139 - 5140
反应条件
1: 1.) NaH / 1.) DMF, room temperature, overnight, 2.) 12 h
2: 80.5 percent / pyridinium dichromate / CH2Cl2 / 96 h
3: 93 percent / NaH / dimethylsulfoxide / Ambient temperature
4: Na, NH3 liquid
5: diethyl ether
6: 77 percent / pyridinium dichromate / CH2Cl2 / 24 h
View Scheme
参考文献
Ackroyd; Manro; Scheinmann; et al.
Tetrahedron Letters, 1983 , vol. 24, # 46 p. 5139 - 5140
反应条件
2: 66 percent / pyridinium chlorochromate
3: 53 percent / potassium t-butoxide
4: Na / liquid ammonia
6: pyridinium chlorochromate
7: 61 percent / Bu-Li / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C
8: aq. KOH / methanol
View Scheme
参考文献
Ackroyd; Manro; Scheinmann; et al.
Tetrahedron Letters, 1983 , vol. 24, # 46 p. 5139 - 5140
反应条件
acetyl chloride
1.) isopropanol, 40 deg C, 5 min, 2.) isopropanol, THF, -40 deg C, 4 5 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Hoock, Ch.; Kasch, H.
Journal fuer Praktische Chemie/Chemiker-Zeitung, 1995 , vol. 337, p. 358 - 362
参考文献
Harris, Michael R.; Hanna, Luke E.; Greene, Margaret A.; Moore, Curtis E.; Jarvo, Elizabeth R.
Journal of the American Chemical Society, 2013 , vol. 135, # 9 p. 3303 - 3306
反应条件
1: NaH
2: (COCl)2; DMSO; TEA
4: TBAF / tetrahydrofuran
View Scheme
参考文献
Wipf; Aslan
Journal of Organic Chemistry, 2001 , vol. 66, # 1 p. 337 - 343
反应条件
acetic acid in tetrahydrofuran; hexane
T=20°C; 1 h;
参考文献
Lysen, Morten; Madden, Maurice; Kristensen, Jesper Langgaard; Vedso, Per; Zoellner, Camilla; Begtrup, Mikael
Synthesis, 2006 , # 20 p. 3478 - 3484
