2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
反应条件
sodium hydroxide
1.) THF, 66 deg C, 1 h, 2.) 66 deg C, 24 h; Yield given. Multistep reaction;
参考文献
Ouchi, Mikio; Inoue, Yoshihisa; Sakamoto, Hidefumi; Yamahira, Atsushi; Yoshinaga, Masanobu; Hakushi, Tadao
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3168 - 3173
反应条件
1: pyridine-3-carbonitrile With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran
T=-78 - 20°C;
2: 3-hydroxy-2,2-dimethylpropanol With acetic acid in tetrahydrofuran
T=20°C; 1 h;
参考文献
Hansen, Henriette M.; Lysen, Morten; Begtrup, Mikael; Kristensen, Jesper L.
Tetrahedron, 2005 , vol. 61, # 42 p. 9955 - 9960
反应条件
1: Py
2: 195 °C
3: aq. KOH / Heating
View Scheme
参考文献
Brown,H.C. et al.
Journal of the American Chemical Society, 1977 , vol. 99, # 2 p. 505 - 509
参考文献
Teulade, Marie-Paule; Savignac, Philippe; Aboujaoude, Elie Elia; Collignon, Noel
Journal of Organometallic Chemistry, 1986 , vol. 312, p. 283 - 296
反应条件
1: PCl3 / CH2Cl2
2: triethylamine / tetrahydrofuran / 1 h / Ambient temperature
3: 82 percent / 3 h / 95 °C
View Scheme
参考文献
Bartle,K.D. et al.
Tetrahedron, 1967 , vol. 23, p. 1701 - 1711
反应条件
1: 90 percent / CH2Cl2 / 1 h / 25 °C
2: 80 percent / diisopropylethylamine / acetonitrile; H2O / 12 h / 70 °C
View Scheme
参考文献
McConnell; Coover
Journal of Organic Chemistry, 1959 , vol. 24, p. 630,634
反应条件
yttria-zirconia based Lewis acid catalyst in chloroform
1 h; Ambient temperature;
参考文献
Pals, Godwin C. G.; Keshavaraja; Saravanan; Kumar, Pradeep
Journal of Chemical Research - Part S, 1996 , # 9 p. 426 - 427
反应条件
toluene-4-sulfonic acid in toluene
2.5 h; Heating;
参考文献
Oehlschlager; Johnston
Journal of Organic Chemistry, 1987 , vol. 52, # 5 p. 940 - 943
反应条件
triethylamine in benzene
参考文献
Ovchinnikov, V. V.; Karataeva, F. Kh.; Cherkasov, R. A.
Russian Journal of General Chemistry, 1995 , vol. 65, # 3.1 p. 361 - 373
Zhurnal Obshchei Khimii, 1995 , vol. 65, # 3 p. 412 - 425
反应条件
1: tri-isopropoxy-borane; 3-methoxybenzylnitrile With 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran; hexane
T=-78 - 20°C;
2: 3-hydroxy-2,2-dimethylpropanol in tetrahydrofuran; hexane
T=20°C; 1 h;
参考文献
Lysen, Morten; Hansen, Henriette M.; Begtrup, Mikael; Kristensen, Jesper L.
Journal of Organic Chemistry, 2006 , vol. 71, # 6 p. 2518 - 2520
