2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
反应条件
triethylamine; phosphorus trichoride
T=100°C;
参考文献
Morita; Kunimoto; Tsuda; Tada; Kise; Kimura
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 10 p. 4144 - 4154
参考文献
Sakoda; Kamikawaji; Seto
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 9 p. 2362 - 2369
反应条件
triethylamine in benzene
参考文献
Motoyoshiya, Jiro; Ikeda, Tsuneaki; Tsuboi, Shuji; Kusaura, Tatsuya; Takeuchi, Yoshino; Hayashi, Satoko; Yoshioka, Sachiko; Takaguchi, Yutaka; Aoyama, Hiromu
Journal of Organic Chemistry, 2003 , vol. 68, # 15 p. 5950 - 5955
反应条件
in toluene
silylation; 0.25 h;
参考文献
Gvozdik; Gal'chenko; Musavirov
Russian Journal of General Chemistry, 1996 , vol. 66, # 5 p. 784 - 787
反应条件
1: 91 percent / KOt-Bu / dioxane / 2 h / 90 °C
2: 93 percent / 1 h / -78 - 0 °C
3: 93 percent / NaH / toluene; tetrahydrofuran / 1 h / 0 - 20 °C
4: 99 percent / DIBAl-H / diethyl ether / 3 h / 0 - 20 °C
5: 96 percent / tBuOOH; Ti(OiPr)4; (-)-diethyl tartrate / CH2Cl2 / -40 - 20 °C
6: 96 percent / Red-Al / tetrahydrofuran / 1 h / 0 °C
7: 98 percent / imidazole / dimethylformamide / 44 h / 60 °C
8: 80 percent / H2 / Pd/C / ethanol / 48 h / 20 °C
9: 97 percent / 1 h / -78 - 0 °C
10: 82 percent / diethyl ether / 0.5 h / 0 °C
11: 80 percent / CrO3; H2SO4 / acetic acid / 2 h
View Scheme
参考文献
Kalesse, Markus; Quitschalle, Monika; Claus, Eckhard; Gerlach, Kai; Pahl, Axel; Meyer, Hartmut H.
European Journal of Organic Chemistry, 1999 , # 11 p. 2817 - 2823
反应条件
1: CsF / 2-methyl-propan-2-ol
2: CsF
View Scheme
参考文献
Ogilvie,K.K. et al.
Journal of the American Chemical Society, 1977 , vol. 99, p. 1277 - 1278
反应条件
1.1: thionyl chloride / dichloromethane / 5 - 10 °C
2.1: dimethyl sulfoxide / 36 h / 100 °C
3.1: pyridine; thionyl chloride / 0 °C
4.1: diethyl ether / 2 h / Reflux
4.2: 3 h / Reflux
5.1: sodium hydrogencarbonate / ethanol / 36 h / 20 °C
View Scheme
参考文献
Liu, Wukun; Zhou, Jinpei; Bensdorf, Kerstin; Zhang, Huibin; Liu, Haoran; Wang, Yubin; Qian, Hai; Zhang, Yanchun; Wellner, Anja; Rubner, Gerhard; Huang, Wenlong; Guo, Cancheng; Gust, Ronald
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 3 p. 907 - 913
反应条件
1: p-toluenesulfonic acid
2: NaNH2 / liquid ammonia / 2 h / Heating
3: 8.56 g / diethyl ether; liquid ammonia / 2 h / Heating
View Scheme
参考文献
Quintana, Jordi; Barrot, Mireia; Fabrias, Gemma; Camps, Francisco
Tetrahedron, 1998 , vol. 54, # 34 p. 10187 - 10198
反应条件
1.1: thionyl chloride / dichloromethane / 0 - 20 °C
2.1: sodium periodate; ruthenium trichloride / dichloromethane; water; acetonitrile / 20 °C
3.1: N,N-dimethyl-formamide / 20 °C
3.2: 80 °C
View Scheme
参考文献
Sund, Christian; Belda, Oscar; Borkakoti, Neera; Lindberg, Jimmy; Derbyshire, Dean; Vrang, Lotta; Hamelink, Elizabeth; Hgren, Cathrine; Woestenenk, Esmeralda; Wikstroem, Kristina; Eneroth, Anders; Lindstroem, Erik; Kalayanov, Genadiy
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6721 - 6727,7
反应条件
1: KMnO4
2: aq. HBr
View Scheme
参考文献
Tanner,D.D. et al.
Canadian Journal of Chemistry, 1977 , vol. 55, p. 612 - 618
