2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
反应条件
1: 3-hydroxy-2,2-dimethylpropanol With sodium hydride in tetrahydrofuran T=0°C; 1 h; Inert atmosphere; 2: TBDMSCl in tetrahydrofuran T=20°C; 3 h; Inert atmosphere;
参考文献
Organic Letters, , vol. 13, # 7 p. 1702 - 1705
反应条件
sodium hydride in tetrahydrofuran 3 h;
参考文献
Chemical Communications, , # 48 p. 5036 - 5038
参考文献
Tetrahedron Letters, , vol. 39, # 23 p. 3919 - 3922
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine 1.) CH2Cl2, -78 deg C, 1 h, 2.) CH2Cl2, 20 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Shinohara, Toshio; Wakita, Kazuhiko; Arai, Midori A.; Arai, Takayoshi; Sasai, Hiroaki
Heterocycles, 2003 , vol. 59, # 2 p. 587 - 593
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in dimethylsulfoxide-d6 T=23°C; product ratio was determined by 1H NMR; Product distribution;
参考文献
Corey; Palani, Anandan
Tetrahedron Letters, 1995 , vol. 36, # 44 p. 7945 - 7948
反应条件
aluminum oxide T=200 - 210°C;
参考文献
Brown; Dougherty
Journal of Organic Chemistry, 1948 , vol. 13, p. 177
参考文献
Brannock; Lappin
Journal of the American Chemical Society, 1955 , vol. 77, p. 6052
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Searles et al.
Journal of Organic Chemistry, 1959 , vol. 24, p. 1770,1773
参考文献
Brown; Dougherty
Journal of Organic Chemistry, 1948 , vol. 13, p. 177
反应条件
Amberlite 15
20 h; Heating; Yield given;
参考文献
Tewes, Bastian; Frehland, Bastian; Schepmann, Dirk; Schmidtke, Kai-Uwe; Winckler, Thomas; Wuensch, Bernhard
ChemMedChem, 2010 , vol. 5, # 5 p. 687 - 695
反应条件
1: Et3N / CH2Cl2 / 1 h / 20 °C
2: Dess-Martin reagent / CH2Cl2
View Scheme
参考文献
Angle, Steven R.; Bernier, Daniel S.; El-Said, Nahla A.; Jones, Darin E.; Shaw, Stephanie Z.
Tetrahedron Letters, 1998 , vol. 39, # 23 p. 3919 - 3922
