2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
参考文献
Voronkov,M.G.; Romadan,Yu.P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1966 , vol. 2, p. 671 - 681
Khimiya Geterotsiklicheskikh Soedinenii, 1966 , vol. 2, # 6 p. 879 - 891
反应条件
sodium methylate; hydroquinone in methanol; toluene T=60 - 70°C; 2 h;
参考文献
EASTMAN CHEMICAL COMPANY
Patent: WO2012/82348 A1, 2012 ;
Location in patent: Page/Page column 23-24 ;
反应条件
methanol; sodium methylate
参考文献
Popescu, Dragos; Hoogenboom, Richard; Keul, Helmut; Moeller, Martin
Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 62, # 1 p. 80 - 89
反应条件
1: 97 percent / p-TsOH / benzene / 19 h / Heating 2: 1.) NaNH2 / 1.) NH3, Et2O, 2.) Et2O, NH3 View Scheme
参考文献
Isaka, Masahiko; Ando, Ryoichi; Morinaka, Yasuhiro; Nakamura, Eiichi
Tetrahedron Letters, 1991 , vol. 32, # 10 p. 1339 - 1342
反应条件
1: 99 percent / toluene / 20 h / Heating 2: 97 percent / N-bromosuccinimide; AIBN / CCl4 / 16 h / Heating View Scheme
参考文献
Chemistry - A European Journal, , vol. 10, # 1 p. 92 - 100
反应条件
1.1: Et3CoLi / tetrahydrofuran / 1.25 h / 20 °C / |Cooling with ice; |Inert atmosphere 1.2: 20 °C / |Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran; hexane / 3 h / -78 - 20 °C / |Inert atmosphere 2.2: 0 - 20 °C View Scheme
参考文献
Elliott, Mark C.; Smith, Keith; Heulyn Jones; Hussain, Ajaz; Saleh, Basil A.
Journal of Organic Chemistry, 2013 , vol. 78, # 7 p. 3057 - 3064
参考文献
European Journal of Medicinal Chemistry, , vol. 55, p. 358 - 374,17
European Journal of Medicinal Chemistry, , vol. 55, p. 358 - 374
反应条件
1: 2,2,6,6-tetramethyl-piperidine; benzonitrile With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran T=-78 - 20°C; 2: 3-hydroxy-2,2-dimethylpropanol in toluene T=20°C;
参考文献
Organic Letters, , vol. 3, # 10 p. 1435 - 1437
反应条件
in toluene T=118°C; 2 h; Heating / reflux;
参考文献
WO2007/57643 A1, ;
Page/Page column 11 ;
WO 2007/057643 A1
反应条件
1.1: thionyl chloride / dichloromethane / 5 - 10 °C 2.1: dimethyl sulfoxide / 36 h / 100 °C 3.1: pyridine; thionyl chloride / 0 °C 4.1: diethyl ether / 2 h / Reflux 4.2: 3 h / Reflux 5.1: sodium hydrogencarbonate / ethanol / 36 h / 20 °C 6.1: tetrahydrofuran / 10 - 15 °C 6.2: 0.33 h / 25 - 30 °C 7.1: hydrazine hydrate; potassium hydroxide / ethylene diglycol / 7 h / 85 - 145 °C View Scheme
参考文献
Liu, Wukun; Zhou, Jinpei; Bensdorf, Kerstin; Zhang, Huibin; Liu, Haoran; Wang, Yubin; Qian, Hai; Zhang, Yanchun; Wellner, Anja; Rubner, Gerhard; Huang, Wenlong; Guo, Cancheng; Gust, Ronald
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 3 p. 907 - 913
