2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
反应条件
1: thien-2-yl bromide With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; tBuCH2CH2B(H)NiPr2; triethylamine; triphenylphosphine in tetrahydrofuran T=65°C; Alcaraz-Vaultier borylation; 12 h; Inert atmosphere; 2: 3-hydroxy-2,2-dimethylpropanol in tetrahydrofuran T=0 - 25°C; 0.25 h; Inert atmosphere; Further stages;
参考文献
Tetrahedron, , vol. 67, # 3 p. 576 - 583
反应条件
1: thiophene With n-butyllithium in tetrahydrofuran; hexane T=-40°C; 1 h; 2: With tributoxyborane in tetrahydrofuran; hexane T=-90°C; 1 h; 3: 3-hydroxy-2,2-dimethylpropanol in tetrahydrofuran; hexane T=20°C; 0.25 h; Further stages.;
参考文献
European Journal of Organic Chemistry, , # 15 p. 2799 - 2812
参考文献
Journal of the American Chemical Society, , vol. 129, # 19 p. 6098 - 6099
反应条件
1.1: 72 percent / BF3*OEt2 / acetonitrile / 16 h / 20 °C 2.1: 85 percent / NaOH / tetrahydrofuran; H2O / 5 h / 20 °C 3.1: Et3N; isobutyl chloroformate / CH2Cl2 / 0.08 h / -20 °C 3.2: 99 percent / CH2Cl2; diethyl ether / 16 h / -20 - 20 °C View Scheme
参考文献
Wardrop, Duncan J.; Forslund, Raymond E.; Landrie, Chad L.; Velter, Adriana I.; Wink, Donald; Surve, Bushan
Tetrahedron Asymmetry, 2003 , vol. 14, # 7 p. 929 - 940
反应条件
2: NaI 3: KOH 4: saponification 5: 180 °C View Scheme
参考文献
Park; Varick; Newcomb
Tetrahedron Letters, 1990 , vol. 31, # 21 p. 2975 - 2978
反应条件
1: in diethyl ether T=0°C; 1 h; 2: With methanesulfonic acid in diethyl ether T=0°C; 0.5 h;
参考文献
Belfrekh, Nicolas; Dietrich-Buchecker, Christiane; Sauvage, Jean-Pierre
Tetrahedron Letters, 2001 , vol. 42, # 15 p. 2779 - 2781
反应条件
sodium unter vermindertem Druck;
参考文献
Arshinova, R.P.; Kadyrov, R.A.; Klochkov, V.V.; Aganov, A.V.; Shakirov, I.Kh.; et al.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, # 11 p. 2301 - 2305
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 11 p. 2512 - 2517
反应条件
indium (III) fluoride in toluene 4.5 h; Reflux; chemoselective reaction;
参考文献
Madabhushi, Sridhar; Mallu, Kishore Kumar Reddy; Chinthala, Narsaiah; Beeram, China Ramanaiah; Vangipuram, Venkata Sairam
Tetrahedron Letters, 2012 , vol. 53, # 6 p. 697 - 701
参考文献
Kristensen, Jesper; Lysen, Morten; Vedso, Per; Begtrup, Mikael
Organic Letters, 2001 , vol. 3, # 10 p. 1435 - 1437
反应条件
toluene-4-sulfonic acid in benzene Heating;
参考文献
Jaeger, Volker; Schohe, Rudolf
Tetrahedron, 1984 , vol. 40, # 12 p. 2199 - 2210
