2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
反应条件
1: Et3N, POCl3 / toluene / 4 h 2: Et3N / toluene View Scheme
参考文献
Raghu; Devendranath Reddy
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996 , vol. 35, # 11 p. 1228 - 1232
反应条件
trimethyl orthoformate; aminopropylated Silica-Gel hydrochloride (APSG*HCl) resin 10 h; Ambient temperature; Yields of byproduct given;
参考文献
Gasparrini, F.; Giovannoli, M.; Misiti, D.; Palmieri, G.
Tetrahedron, 1984 , vol. 40, # 9 p. 1491 - 1500
反应条件
1: 33 percent / 100 °C 2: 65.8 percent / diethyl ether / 7 h / Heating 3: 31 percent / piperidine, acetic acid / benzene / 6.5 h / Heating 4: 45 percent / toluene / 5 h / Heating View Scheme
参考文献
Sakoda; Kamikawaji; Seto
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 9 p. 2362 - 2369
反应条件
1 Pd/TiO2; oxygen; sodium hydroxide T=80°C; P=2250.23 Torr; 24 h;
参考文献
D'Agostino, Carmine; Kotionova, Tatyana; Mitchell, Jonathan; Miedziak, Peter J.; Knight, David W.; Taylor, Stuart H.; Hutchings, Graham J.; Gladden, Lynn F.; Mantle, Mick D.
Chemistry - A European Journal, 2013 , vol. 19, # 35 p. 11725 - 11732
反应条件
potassium permanganate
参考文献
Tanner,D.D. et al.
Canadian Journal of Chemistry, 1977 , vol. 55, p. 612 - 618
反应条件
1 Au-Pd/TiO2; oxygen; sodium hydroxide T=80°C; P=2250.23 Torr; 4 h;
参考文献
Kotionova, Tatyana; Lee, Christopher; Miedziak, Peter J.; Dummer, Nicholas F.; Willock, David J.; Carley, Albert F.; Morgan, David J.; Knight, David W.; Taylor, Stuart H.; Hutchings, Graham J.
Catalysis Letters, 2012 , vol. 142, # 9 p. 1114 - 1120
反应条件
1: p-toluenesulfonic acid / toluene / 24 h / Heating 2: 60 percent / Collins reagent (from chromic oxide, pyridine) / CH2Cl2 / 0.33 h / 15 °C View Scheme
参考文献
Deslongchamps; Belanger; Berney; Borschberg; Brousseau; Doutheau; Durand; Katayama; Lapalme; Leturc; Liao; MacLachlan; Maffrand; Marazza; Martino; Moreau; Ruest; Saint-Laurent; Saintonge; et al.
Canadian Journal of Chemistry, 1990 , vol. 68, # 1 p. 127 - 152
反应条件
1.1: thionyl chloride / dichloromethane / 5 - 10 °C 2.1: dimethyl sulfoxide / 36 h / 100 °C 3.1: pyridine; thionyl chloride / 0 °C 4.1: diethyl ether / 2 h / Reflux 4.2: 3 h / Reflux View Scheme
参考文献
Liu, Wukun; Zhou, Jinpei; Bensdorf, Kerstin; Zhang, Huibin; Liu, Haoran; Wang, Yubin; Qian, Hai; Zhang, Yanchun; Wellner, Anja; Rubner, Gerhard; Huang, Wenlong; Guo, Cancheng; Gust, Ronald
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 3 p. 907 - 913
反应条件
1 Pd/TiO2; oxygen; sodium hydroxide T=80°C; P=2250.23 Torr; 24 h;
参考文献
D'Agostino, Carmine; Kotionova, Tatyana; Mitchell, Jonathan; Miedziak, Peter J.; Knight, David W.; Taylor, Stuart H.; Hutchings, Graham J.; Gladden, Lynn F.; Mantle, Mick D.
Chemistry - A European Journal, 2013 , vol. 19, # 35 p. 11725 - 11732
反应条件
1 Au-Pd/TiO2; oxygen; sodium hydroxide T=80°C; P=2250.23 Torr; 4 h;
参考文献
Kotionova, Tatyana; Lee, Christopher; Miedziak, Peter J.; Dummer, Nicholas F.; Willock, David J.; Carley, Albert F.; Morgan, David J.; Knight, David W.; Taylor, Stuart H.; Hutchings, Graham J.
Catalysis Letters, 2012 , vol. 142, # 9 p. 1114 - 1120
