2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
反应条件
triethylamine T=65 - 90°C; 0.666667 h; Nitrogen atmosphere;
参考文献
EP1598357 A1, ;
Page/Page column 5 ;
反应条件
water; methyllithium; calcium carbonate
参考文献
Justus Liebigs Annalen der Chemie, , vol. 289, p. 38
Chemische Berichte, , vol. 27, p. 1088
反应条件
1.1: lithium (R,R)-bis(phenylethyl)amide; LiCl / tetrahydrofuran; hexane / 0.67 h / -100 °C 1.2: tetrahydrofuran; hexane / 0.5 h / -100 °C 2.1: NCS / CH2Cl2 / 1 h / 20 °C 2.2: aq. AcOH / tetrahydrofuran / 2 h / 20 °C 3.1: diethyl ether / 48 h / 0 °C 4.1: aq. NaHCO3 / diethyl ether / 0.05 h / 20 °C 5.1: t-BuLi / pentane; diethyl ether / 0.5 h / -78 °C 5.2: [(n-Bu3P)CuI]4 / pentane; diethyl ether / 0.67 h / -10 °C 5.3: 80 percent / pentane; diethyl ether; tetrahydrofuran / 0.5 h / -60 °C 6.1: benzeneseleninic anhydride / tetrahydrofuran / 1 h / 20 °C 7.1: 515 mg / NaBH4 / ethanol / 7 h / -40 °C 8.1: p-TsOH; water / acetone / 12 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 124, # 16 p. 4321 - 4328
反应条件
triethylamine T=40 - 90°C; Aldol Condensation; 0.666667 h;
参考文献
EP1568678 A1, ;
Page/Page column 5 ;
反应条件
1.1: t-BuLi / pentane; diethyl ether / 0.5 h / -78 °C 1.2: [(n-Bu3P)CuI]4 / pentane; diethyl ether / 0.67 h / -10 °C 1.3: 80 percent / pentane; diethyl ether; tetrahydrofuran / 0.5 h / -60 °C 2.1: benzeneseleninic anhydride / tetrahydrofuran / 1 h / 20 °C 3.1: 515 mg / NaBH4 / ethanol / 7 h / -40 °C 4.1: p-TsOH; water / acetone / 12 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 124, # 16 p. 4321 - 4328
反应条件
1.1: NCS / CH2Cl2 / 1 h / 20 °C 1.2: aq. AcOH / tetrahydrofuran / 2 h / 20 °C 2.1: diethyl ether / 48 h / 0 °C 3.1: aq. NaHCO3 / diethyl ether / 0.05 h / 20 °C 4.1: t-BuLi / pentane; diethyl ether / 0.5 h / -78 °C 4.2: [(n-Bu3P)CuI]4 / pentane; diethyl ether / 0.67 h / -10 °C 4.3: 80 percent / pentane; diethyl ether; tetrahydrofuran / 0.5 h / -60 °C 5.1: benzeneseleninic anhydride / tetrahydrofuran / 1 h / 20 °C 6.1: 515 mg / NaBH4 / ethanol / 7 h / -40 °C 7.1: p-TsOH; water / acetone / 12 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 124, # 16 p. 4321 - 4328
反应条件
1.1: diethyl ether / 48 h / 0 °C 2.1: aq. NaHCO3 / diethyl ether / 0.05 h / 20 °C 3.1: t-BuLi / pentane; diethyl ether / 0.5 h / -78 °C 3.2: [(n-Bu3P)CuI]4 / pentane; diethyl ether / 0.67 h / -10 °C 3.3: 80 percent / pentane; diethyl ether; tetrahydrofuran / 0.5 h / -60 °C 4.1: benzeneseleninic anhydride / tetrahydrofuran / 1 h / 20 °C 5.1: 515 mg / NaBH4 / ethanol / 7 h / -40 °C 6.1: p-TsOH; water / acetone / 12 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 124, # 16 p. 4321 - 4328
反应条件
1: 80 percent / pentane / 1.) 0 deg C, overnight, 2.) room temperature, 5 days 2: 96.2 percent / 10percent HCl / tetrahydrofuran / 1 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 109, p. 4940
反应条件
1: 90.6 percent / lithium / tetrahydrofuran; diethyl ether / 2.5 h / 0 °C 2: 80 percent / pentane / 1.) 0 deg C, overnight, 2.) room temperature, 5 days 3: 96.2 percent / 10percent HCl / tetrahydrofuran / 1 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 109, p. 4940
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 1 h;
参考文献
Tetrahedron Asymmetry, , vol. 14, # 21 p. 3371 - 3378
