2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
反应条件
1: tri-isopropoxy-borane; para-bromobenzonitrile; lithium diisopropyl amide 2: 3-hydroxy-2,2-dimethylpropanol Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 71, # 6 p. 2518 - 2520
反应条件
in n-heptane; toluene
参考文献
Brantford Chemicals Inc.
Patent: US6307066 B1, 2001 ;
反应条件
tri-ruthenium(0)dodecacarbonyl; 4,5-bis-(di-isopropylphosphinomethyl)acridine; ammonia in 1,1-dimethylpropan-1-ol T=170°C; 21 h; Inert atmosphereSchlenk techniqueAutoclave; Temperature;
参考文献
Pingen, Dennis; Diebolt, Olivier; Vogt, Dieter
ChemCatChem, 2013 , vol. 5, # 10 p. 2905 - 2912
参考文献
Gobbi, Luca Claudio; Gubler, Marcel; Neidhart, Werner; Nettekoven, Matthias Heinrich
Patent: US2005/113374 A1, 2005 ;
Location in patent: Page/Page column 7; 14-15 ;
反应条件
potassium cyanide; sodium hydroxide in pyridine; methanol; dichloromethane; water; ethylene glycol; N,N-dimethyl-formamide
参考文献
Avanir Pharmaceuticals
Patent: US6271390 B1, 2001 ;
反应条件
sodium hydride 1) THF, 30 min, r.t., 2) THF, 6 h, reflux; Yield given. Multistep reaction;
参考文献
Weber, Edwin
Chemische Berichte, 1981 , vol. 114, # 4 p. 1551 - 1553
反应条件
1: 2-pyridine carbonitrile With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran T=-78 - 20°C; 2: 3-hydroxy-2,2-dimethylpropanol With acetic acid in tetrahydrofuran T=20°C; 1 h;
参考文献
Hansen, Henriette M.; Lysen, Morten; Begtrup, Mikael; Kristensen, Jesper L.
Tetrahedron, 2005 , vol. 61, # 42 p. 9955 - 9960
反应条件
in 1,4-dioxane 18 h; Molecular sieveReflux;
参考文献
Journal of Fluorine Chemistry, , vol. 130, # 4 p. 377 - 382
反应条件
sulfuric acid in water Heating;
参考文献
Bailey, William F.; Rivera, Alberto D.
Journal of Organic Chemistry, 1984 , vol. 49, # 25 p. 4958 - 4964
反应条件
ammonia; hydrogen; Co-Fe catalyst T=210°C; P=37503 - 112509 Torr; Product distribution;
参考文献
Fischer, Achim; Mallat, Tamas; Baiker, Alfons
Angewandte Chemie - International Edition, 1999 , vol. 38, # 3 p. 351 - 354
