2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
反应条件
sodium hydroxide; sodium hydrogencarbonate; toluene-4-sulfonic acid in dichloromethane; water
参考文献
Puetz, Claudia; Buschmann, Helmut; Koegel, Babette-Yvonne
Patent: US2003/96811 A1, 2003 ;
反应条件
1: para-iodoanisole With tBuCH2CH2B(H)NiPr2; triethylamine; triphenylphosphine; palladium dichloride in tetrahydrofuran T=65°C; Alcaraz-Vaultier borylation; 12 h; Inert atmosphere; 2: 3-hydroxy-2,2-dimethylpropanol in tetrahydrofuran T=0 - 25°C; 0.25 h; Inert atmosphere; Further stages;
参考文献
Tetrahedron, , vol. 67, # 3 p. 576 - 583
反应条件
1: 3-hydroxy-2,2-dimethylpropanol With tetrakis(dimethylamino)diboron; potassium acetate in toluene T=80°C; 0.5 h; 2: 1-bromo-4-methoxy-benzene With tetrakis(triphenylphosphine) palladium(0) in toluene T=80°C; 22 h;
参考文献
WO2013/14579 A1, ;
Page/Page column 11; 12; 13 ;
反应条件
silica gel in water T=20°C; 0.5 h; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 74, # 19 p. 7364 - 7369
反应条件
in tetrahydrofuran 0.666667 h; Dean-StarkReflux;
参考文献
Advanced Synthesis and Catalysis, , vol. 356, # 7 p. 1527 - 1532
反应条件
1: tris(4-methoxyphenyl)stilbane With boron trichloride in dichloromethane T=0°C; 2 h; 2: With methanol T=20°C; 0.5 h; 3: 3-hydroxy-2,2-dimethylpropanol in methanol T=20°C; 1 h;
参考文献
Chemistry Letters, , vol. 35, # 12 p. 1402 - 1403
反应条件
NaOC(CH3)3; 2,4,6-(i-Pr)3C6H2C6H4[2-P(cyclo-C6H11)2]; KOAc in ethanol mixt. org. compound, B2(OH)4, Pd-complex, (iPr)3C6H2C6H4-2-P(cyclo-C6H11), NaOBu-t and excess KOAc in EtOH at 80°C for 18 h;
参考文献
Journal of the American Chemical Society, , vol. 132, # 50 p. 17701 - 17703
反应条件
1: dimethylsulfide borane complex / toluene / 2 h / 0 - 20 °C / Inert atmosphere 2: [1,3-bis(diphenylphosphino) propane] dichloronickel(II); triethylamine; triphenylphosphine; zinc / toluene / 100 °C / Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 2 p. 1018 - 1025
反应条件
in dichloromethane all reactions under Ar atm.; soln. of BCl3 in CH2Cl2 added to stirred soln. of triarylstibane at 0°C, stirred for 2 h, allowed to warm toroom temp., solvent removed in vac., oil dissolved in MeOH, stirred for 30 min at room temp., diol added; stirred for 1 h, solvent removed in vac., chromy. (silica-gel, hexane/CH2Cl2);
参考文献
Chemistry Letters, , vol. 35, # 12 p. 1402 - 1403
反应条件
potassium phosphate in tetrahydrofuran Kinetics;
参考文献
Journal of Organic Chemistry, , vol. 77, # 14 p. 5956 - 5964
