2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
反应条件
magnesium sulfate in diethyl ether T=25°C; 20 h; Inert atmosphere;
参考文献
Matthew, Smitha C.; Glasspoole, Ben W.; Eisenberger, Patrick; Crudden, Cathleen M.
Journal of the American Chemical Society, 2014 , vol. 136, # 16 p. 5828 - 5831
反应条件
1: 3-hydroxy-2,2-dimethylpropanol With tetrakis(dimethylamino)diboron; potassium acetate in tetrahydrofuran T=80°C; 0.5 h; 2: trifluoromethanesulfonyloxybenzene With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triphenylphosphine in tetrahydrofuran T=80°C; 22 h;
参考文献
BASF SE; SCHMIDT-LEITHOFF, Joachim; PICHLMAIR, Stefan; BELLO, Charles; BASF (CHINA) COMPANY LIMITED
Patent: WO2013/14579 A1, 2013 ;
Location in patent: Page/Page column 15; 16 ;
反应条件
1: tri-phenyl-antimony With boron trichloride in dichloromethane T=0°C; 2 h; 2: With methanol T=20°C; 0.5 h; 3: 3-hydroxy-2,2-dimethylpropanol in methanol T=20°C; 1 h;
参考文献
Yasuike, Shuji; Nakata, Kazuhide; Qin, Weiwei; Kaji, Toshiyuki; Kurita, Jyoji
Chemistry Letters, 2006 , vol. 35, # 12 p. 1402 - 1403
反应条件
1: Ph2SbCl With boron trichloride in dichloromethane T=0°C; 2 h; 2: With methanol T=20°C; 0.5 h; 3: 3-hydroxy-2,2-dimethylpropanol in methanol T=20°C; 1 h;
参考文献
Yasuike, Shuji; Nakata, Kazuhide; Qin, Weiwei; Kaji, Toshiyuki; Kurita, Jyoji
Chemistry Letters, 2006 , vol. 35, # 12 p. 1402 - 1403
反应条件
1: dichloromonophenylantimony(III) With boron trichloride in dichloromethane T=0°C; 2 h; 2: With methanol T=20°C; 0.5 h; 3: 3-hydroxy-2,2-dimethylpropanol in methanol T=20°C; 1 h;
参考文献
Yasuike, Shuji; Nakata, Kazuhide; Qin, Weiwei; Kaji, Toshiyuki; Kurita, Jyoji
Chemistry Letters, 2006 , vol. 35, # 12 p. 1402 - 1403
反应条件
1: triphenylbismuthine With boron trichloride in dichloromethane T=-78°C; 4 h; 2: With methanol T=20°C; 0.5 h; 3: 3-hydroxy-2,2-dimethylpropanol in methanol T=20°C; 1 h;
参考文献
Yasuike, Shuji; Nakata, Kazuhide; Qin, Weiwei; Kaji, Toshiyuki; Kurita, Jyoji
Chemistry Letters, 2006 , vol. 35, # 12 p. 1402 - 1403
反应条件
in chloroform-d1 Kinetics; byproducts: HOCH2CH2OH; inder inert atm., at 25°C, for 0.1 h, in NMR tube; monitoring by (1)H NMR;
参考文献
Roy, Chandra D.; Brown, Herbert C.
Journal of Organometallic Chemistry, 2007 , vol. 692, # 4 p. 784 - 790
反应条件
1: dimethylsulfide borane complex / toluene / 2 h / 0 - 20 °C / Inert atmosphere 2: [1,3-bis(diphenylphosphino) propane] dichloronickel(II); triethylamine; triphenylphosphine; zinc / toluene / 100 °C / Inert atmosphere View Scheme
参考文献
Bowie,R.A.; Musgrave,O.C.
Journal of the Chemical Society [Section] C: Organic, 1970 , p. 485 - 488
反应条件
in dichloromethane all reactions under Ar atm.; soln. of BCl3 in CH2Cl2 added to stirred soln. of triarylstibane at 0°C, stirred for 2 h, allowed to warm toroom temp., solvent removed in vac., oil dissolved in MeOH, stirred for 30 min at room temp., diol added; stirred for 1 h, solvent removed in vac., chromy. (silica-gel, hexane/CH2Cl2);
参考文献
Yasuike, Shuji; Nakata, Kazuhide; Qin, Weiwei; Kaji, Toshiyuki; Kurita, Jyoji
Chemistry Letters, 2006 , vol. 35, # 12 p. 1402 - 1403
反应条件
in dichloromethane all reactions under Ar atm.; soln. of BCl3 in CH2Cl2 added to stirred soln. of triarylstibane at 0°C, stirred for 2 h, allowed to warm toroom temp., solvent removed in vac., oil dissolved in MeOH, stirred for 30 min at room temp., diol added; stirred for 1 h, solvent removed in vac., chromy. (silica-gel, hexane/CH2Cl2);
参考文献
Yasuike, Shuji; Nakata, Kazuhide; Qin, Weiwei; Kaji, Toshiyuki; Kurita, Jyoji
Chemistry Letters, 2006 , vol. 35, # 12 p. 1402 - 1403
