(-)-表儿茶素没食子酸酯合成路线 （共 50 条）
反应条件
5 Pd(OH)2/C; hydrogen in tetrahydrofuran; methanol; water T=20°C; 0.5 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 8, # 12 p. 2693 - 2696
反应条件
1.1: 47.3 percent / silica gel supported H2SO4 / CH2Cl2 / 20 °C 2.1: imidazole / dimethylformamide / 20 °C 3.1: AD-mixα; methanesulfonamide / H2O; 2-methyl-propan-2-ol; CH2Cl2 / 0 °C 4.1: TBAF / tetrahydrofuran / 4 h / 20 °C 5.1: triethyl orthoformate; pyridinium p-toluenesulfonate / 1,2-dichloro-ethane / 5 h / 60 °C 5.2: K2CO3 / methanol; 1,2-dimethoxy-ethane / 20 °C 6.1: 76 percent / Dess-Martin periodinane / CH2Cl2 / 2 h / 20 °C 7.1: 90 percent / L-Selectride / tetrahydrofuran / -78 °C 8.1: 80 percent / DMAP / CH2Cl2 / 20 °C 9.1: 80 percent / H2 / Pd(OH)2/C / methanol; tetrahydrofuran / 6 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 13 p. 3521 - 3527
反应条件
1: oxalyl chloride; DMF / CH2Cl2 / 3 h / Heating 2: 80 percent / DMAP / CH2Cl2 / 20 °C 3: 80 percent / H2 / Pd(OH)2/C / methanol; tetrahydrofuran / 6 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 13 p. 3521 - 3527
反应条件
1: 80 percent / DMAP / CH2Cl2 / 20 °C 2: 80 percent / H2 / Pd(OH)2/C / methanol; tetrahydrofuran / 6 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 13 p. 3521 - 3527
反应条件
1: 76 percent / Dess-Martin periodinane / CH2Cl2 / 2 h / 20 °C 2: 90 percent / L-Selectride / tetrahydrofuran / -78 °C 3: 80 percent / DMAP / CH2Cl2 / 20 °C 4: 80 percent / H2 / Pd(OH)2/C / methanol; tetrahydrofuran / 6 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 13 p. 3521 - 3527
反应条件
1: 80 percent / DMAP / CH2Cl2 / 20 °C 2: 80 percent / H2 / Pd(OH)2/C / methanol; tetrahydrofuran / 6 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 13 p. 3521 - 3527
反应条件
1: 90 percent / L-Selectride / tetrahydrofuran / -78 °C 2: 80 percent / DMAP / CH2Cl2 / 20 °C 3: 80 percent / H2 / Pd(OH)2/C / methanol; tetrahydrofuran / 6 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 13 p. 3521 - 3527
反应条件
1.1: imidazole / dimethylformamide / 20 °C 2.1: AD-mixα; methanesulfonamide / H2O; 2-methyl-propan-2-ol; CH2Cl2 / 0 °C 3.1: TBAF / tetrahydrofuran / 4 h / 20 °C 4.1: triethyl orthoformate; pyridinium p-toluenesulfonate / 1,2-dichloro-ethane / 5 h / 60 °C 4.2: K2CO3 / methanol; 1,2-dimethoxy-ethane / 20 °C 5.1: 76 percent / Dess-Martin periodinane / CH2Cl2 / 2 h / 20 °C 6.1: 90 percent / L-Selectride / tetrahydrofuran / -78 °C 7.1: 80 percent / DMAP / CH2Cl2 / 20 °C 8.1: 80 percent / H2 / Pd(OH)2/C / methanol; tetrahydrofuran / 6 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 13 p. 3521 - 3527
反应条件
1.1: triethyl orthoformate; pyridinium p-toluenesulfonate / 1,2-dichloro-ethane / 5 h / 60 °C 1.2: K2CO3 / methanol; 1,2-dimethoxy-ethane / 20 °C 2.1: 76 percent / Dess-Martin periodinane / CH2Cl2 / 2 h / 20 °C 3.1: 90 percent / L-Selectride / tetrahydrofuran / -78 °C 4.1: 80 percent / DMAP / CH2Cl2 / 20 °C 5.1: 80 percent / H2 / Pd(OH)2/C / methanol; tetrahydrofuran / 6 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 13 p. 3521 - 3527
反应条件
1.1: AD-mixα; methanesulfonamide / H2O; 2-methyl-propan-2-ol; CH2Cl2 / 0 °C 2.1: TBAF / tetrahydrofuran / 4 h / 20 °C 3.1: triethyl orthoformate; pyridinium p-toluenesulfonate / 1,2-dichloro-ethane / 5 h / 60 °C 3.2: K2CO3 / methanol; 1,2-dimethoxy-ethane / 20 °C 4.1: 76 percent / Dess-Martin periodinane / CH2Cl2 / 2 h / 20 °C 5.1: 90 percent / L-Selectride / tetrahydrofuran / -78 °C 6.1: 80 percent / DMAP / CH2Cl2 / 20 °C 7.1: 80 percent / H2 / Pd(OH)2/C / methanol; tetrahydrofuran / 6 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 13 p. 3521 - 3527
