2,4-二氟-5-硝基苯甲酸甲酯合成路线 （共 5 条）
反应条件
hydrogenchloride in 1,4-dioxane 16 h; Heating / reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO KG
Patent: WO2007/19674 A1, 2007 ;
Location in patent: Page/Page column 45 ;
反应条件
sulfuric acid in methanol 1.5 h; Heating / reflux;
参考文献
Shionogi and Co., Ltd.
Patent: WO2005/121132 A1, 2005 ;
Location in patent: Page/Page column 227-228 ;
反应条件
sulfuric acid; nitric acid
反应条件
Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 55, # 7 p. 2034 - 2044
反应条件
iron; acetic acid in water T=40°C; 1.5 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/58923 A1, 2009 ;
Location in patent: Page/Page column 12 ;
WO 2009/058923 A1
