1-N-Boc-4-苯胺基哌啶合成路线 （共 11 条）
反应条件
sodium tris(acetoxy)borohydride in dichloromethane T=20°C; 2 h; Inert atmosphere;
参考文献
ChemMedChem, , vol. 6, # 4 p. 654 - 666
反应条件
sodium hydroxide; sodium tris(acetoxy)borohydride; acetic acid; aniline in diethyl ether; dichloromethane
反应条件
sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; sodium sulfate; aniline in acetic acid
反应条件
palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate in 1,4-dioxane T=100°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 3 p. 427 - 431
反应条件
1: H2 / Pd/C / methanol 2: Pd(OAc)2; BINAP; NaO-t-Bu / dioxane / 100 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 3 p. 427 - 431
反应条件
titanium(IV) isopropylate; sodium tetrahydroborate a) room temperature, b) ethanol;
参考文献
Journal of Organic Chemistry, , vol. 55, # 8 p. 2552 - 2554
反应条件
1: CH2Cl2 / 0.5 h 2: NaBH(OAc)3 / CH2Cl2 / 18 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 8, # 6 p. 1203 - 1212
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Berlin, Michael; Lee, Yoon Joo; Boyce, Christopher W.; Wang, Yi; Aslanian, Robert; McCormick, Kevin D.; Sorota, Steve; Williams, Shirley M.; West Jr., Robert E.; Korfmacher, Walter
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 7 p. 2359 - 2364
反应条件
1: 52 percent / Pd(OAc)2; BINAP; t-BuOK / tetrahydrofuran; toluene / 16 h / 110 °C
2: aq. TFA / 3 h / 25 °C
View Scheme
参考文献
Dittrich, Torsten; Hanekop, Nils; Infed, Nacera; Schmitt, Lutz; Braun, Manfred
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1700 - 1704
反应条件
tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate in toluene
T=100°C; Buchwald-Hartwig Coupling; 16 h; Inert atmosphere;
参考文献
Dittrich, Torsten; Hanekop, Nils; Infed, Nacera; Schmitt, Lutz; Braun, Manfred
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1700 - 1704
