1: N-[4-(4-fIuoro-phenyl)-6-isopropyI-5-(pyridine-2-sulfonyImethyl)-pyrimidin-2-yl]-N-methyI-methanesuIfonamide With potassium carbonate in dimethyl sulfoxide T=35 - 40°C; 2: 1,1-Dimethylethyl 6-formyl-2,2-dimethyl-1,3-dioxane-4-acetate in dimethyl sulfoxide T=75 - 80°C; 12 h;

1: N-[5-(3,5-bis-trifluoromethyl-benzenesulfonyl methyl)-4-(4-fluoro-phenyl)-6-isopropyI-pyrimidin-2-yI]-N-methyl-methanesulfonamide With potassium carbonate in dimethyl sulfoxide T=35 - 40°C; 2: 1,1-Dimethylethyl 6-formyl-2,2-dimethyl-1,3-dioxane-4-acetate in dimethyl sulfoxide T=75 - 80°C; 12 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1696847', constants.ctx, '0')">dimethylsulfide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '4921393', constants.ctx, '0')">ozone</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />&nbsp;1.) -78 deg C, 2.) RT, 16 h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: H+<br />2: 1) O₃, 2) Me₂S / 1) CH₂Cl₂, -78 deg C<br /> <br /> &nbsp;