[2-丁基-4-氯-1-[(2’-(1-三苯甲基-1H-四氮唑-5-基)联苯-4-基)甲基)-1H-咪唑-5-基)甲醇合成路线 （共 18 条）
反应条件
7 h; Heating / reflux;
参考文献
WO2005/21535 A2, ;
Page/Page column 10 ;
反应条件
Heating / reflux; Product distribution / selectivity;
参考文献
ZENTIVA, a.s.
Patent: WO2005/21535 A2, 2005 ;
Location in patent: Page/Page column 13-14 ;
反应条件
potassium hydroxide in methanol; water Heating / reflux; Purification / work up;
参考文献
US2004/97568 A1, ;
Page/Page column 5-6 ;
反应条件
Heating / reflux; Product distribution / selectivity;
参考文献
WO2005/21535 A2, ;
Page/Page column 13-14 ;
反应条件
1: With hydroxylamine hydrochloride in methanol T=60°C; pH=2.95; 2.5 h; 2: With triethylamine in methanol T=0 - 40°C; pH=3.6; 1 h; Product distribution / selectivity;
参考文献
ULKAR KIMYA SANAYII VE TICARET A.S.
Patent: WO2006/97121 A1, 2006 ;
Location in patent: Page/Page column 11-12 ;
反应条件
1: With hydroxylamine hydrochloride in methanol; water; acetone T=20°C; 2 h; 2: With sodium hydroxide in methanol; water; acetone T=20 - 25°C; pH=3.8 - 4.2;
参考文献
ULKAR KIMYA SANAYII VE TICARET AS
Patent: WO2006/98705 A1, 2006 ;
Location in patent: Page/Page column 10-11 ;
反应条件
7 h; Heating / reflux;
参考文献
WO2005/21535 A2, ;
Page/Page column 10 ;
反应条件
manganese(IV) dioxide in dichloromethane; 1,2-dichloro-ethane
参考文献
US5298517 A1, ;
US 5298517 A
