N-Boc-4-哌啶甲酸甲酯合成路线 （共 29 条）
反应条件
1: LDA / tetrahydrofuran / -78 °C 2: KOH / methanol / Heating View Scheme
参考文献
Jiang, Xiao-Hua; Song, Yan-Li; Long, Ya-Qiu
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 14 p. 3675 - 3678
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / |Inert atmosphere 1.2: -78 - 20 °C / |Inert atmosphere 2.1: lithium hydroxide hydrate / tetrahydrofuran; water / 45 °C 3.1: triethylamine; diphenyl phosphoryl azide / toluene / 20 - 80 °C / |Inert atmosphere 4.1: hydrogenchloride / 1,4-dioxane / 50 °C View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.
Patent: WO2013/19621 A1, 2013 ;
WO 2013/019621 A1
反应条件
1: LDA / tetrahydrofuran / -78 °C 2: KOH / methanol / Heating View Scheme
参考文献
Jiang, Xiao-Hua; Song, Yan-Li; Long, Ya-Qiu
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 14 p. 3675 - 3678
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / |Inert atmosphere 1.2: -78 - 20 °C / |Inert atmosphere 2.1: lithium hydroxide hydrate / tetrahydrofuran; water / 45 °C 3.1: triethylamine; diphenyl phosphoryl azide / toluene / 20 - 80 °C / |Inert atmosphere View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.
Patent: WO2013/19621 A1, 2013 ;
WO 2013/019621 A1
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / |Inert atmosphere 1.2: -78 - 20 °C / |Inert atmosphere 2.1: lithium hydroxide hydrate / tetrahydrofuran; water / 45 °C View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.
Patent: WO2013/19621 A1, 2013 ;
WO 2013/019621 A1
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -65 °C / |Inert atmosphere 1.2: -65 - 20 °C / |Inert atmosphere 2.1: ammonium hydroxide; hydrogen / methanol / 18 h / 50 °C / 15001.5 Torr View Scheme
参考文献
WO2014/15495 A1, ;
WO2014/18764 A1, ;
反应条件
1: methyl N-tert-butoxycarbonyl-piperidine-4-carboxylate With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-78°C; 1.5 h;
2: benzyl bromide in tetrahydrofuran; hexane
T=-78°C; 2.5 h;
参考文献
Fan, Xing; Zhang, Hu-Shan; Chen, Li; Long, Ya-Qiu
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 7 p. 2827 - 2840
反应条件
1: LDA / tetrahydrofuran / -78 °C
2: KOH / methanol / Heating
3: NMM / tetrahydrofuran / 1 h / -15 °C
4: aq. NaN3 / tetrahydrofuran / -15 - 20 °C
5: toluene / 1.5 h / 90 °C
6: aq. KOH / tetrahydrofuran / 0 °C
View Scheme
参考文献
Jiang, Xiao-Hua; Song, Yan-Li; Long, Ya-Qiu
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 14 p. 3675 - 3678
反应条件
1: LDA / tetrahydrofuran / -78 °C
2: LAH / tetrahydrofuran / 20 °C
3: SO3*Py; NEt3 / dimethylsulfoxide / 20 °C
View Scheme
参考文献
Ogino, Yoshio; Ohtake, Norikazu; Kobayashi, Kensuke; Kimura, Toshifumi; Fujikawa, Toru; Hasegawa, Takuro; Noguchi, Kazuhito; Mase, Toshiaki
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 13 p. 2167 - 2172
