3-硝基-5,6,7,8-四氢-[1,6]萘啶合成路线 （共 6 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 18 h;
参考文献
WO2006/12374 A1, ;
Page/Page column 228 ;
WO 2006/012374 A1
反应条件
hydrogenchloride 1.5 h; Heating;
参考文献
Marcelis, Antonius T. M.; Plas, Henk C. van der
Tetrahedron, 1989 , vol. 45, # 9 p. 2693 - 2702
反应条件
1: 48 percent / ethanol / 3 h / Heating 2: 89 percent / 6N hydrochloric acid / 1.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 45, # 9 p. 2693 - 2702
反应条件
10 Pd/C; hydrogen in methanol
参考文献
Shah, Unmesh; Lankin, Claire M.; Boyle, Craig D.; Chackalamannil, Samuel; Greenlee, William J.; Neustadt, Bernard R.; Cohen-Williams, Mary E.; Higgins, Guy A.; Ng, Kwokei; Varty, Geoffrey B.; Zhang, Hongtao; Lachowicz, Jean E.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 14 p. 4204 - 4209
反应条件
palladium on activated charcoal in pentan-1-ol
T=180°C; 1 h; Microwave irradiation;
参考文献
AMGEN INC.
Patent: WO2006/12374 A1, 2006 ;
Location in patent: Page/Page column 229 ;
WO 2006/012374 A1
反应条件
10 Pd/C; hydrogen in methanol
参考文献
Shah, Unmesh; Lankin, Claire M.; Boyle, Craig D.; Chackalamannil, Samuel; Greenlee, William J.; Neustadt, Bernard R.; Cohen-Williams, Mary E.; Higgins, Guy A.; Ng, Kwokei; Varty, Geoffrey B.; Zhang, Hongtao; Lachowicz, Jean E.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 14 p. 4204 - 4209
