1: 90 percent / Amberlyst A 26 (OH-) / methanol / 6 h / Ambient temperature 2: 1) NaH (50percent in mineral oil) / 1) THF a) 0 deg C b) 1h room temperature 2) 1.5h, 0 deg C 3: 95 percent / N-iodosuccinimide / CHCl3 / 8 h / Ambient temperature 4: 95 percent / 2N HCl / methanol / 24 h / Ambient temperature 5: 88 percent / tri-n-butyltin hydride, azobis(isobutyronitrile) / benzene; methanol / 5 h / Heating View Scheme

&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '969212', constants.ctx, '0')">benzene</a> <br />12&nbsp;h;&nbsp;&nbsp;Heating;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 90 percent / triethylamine, (N,N-dimethylamino)pyridine / CH₂Cl₂ / 0.5 h / 0 &deg;C<br />2: 65 percent / benzene / 12 h / Heating<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '110354', constants.ctx, '0')">4-(N,N-dimethlyamino)pyridine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=20&deg;C;&nbsp;6&nbsp;h;&nbsp;&nbsp;optical yield given as percent de;&nbsp;<br /> &nbsp;