(S)-1,2-环氧基戊烷合成路线 （共 11 条）
反应条件
potassium hydroxide T=25°C; 1 h;
参考文献
Margot, Christian; Simmons, Dana P.; Reichlin, Daniel; Skuy, David
Helvetica Chimica Acta, 2004 , vol. 87, # 10 p. 2662 - 2684
反应条件
sodium hydroxide in diethyl ether T=20°C; 22 h;
参考文献
Nagano, Takashi; Pospisil, Jiri; Chollet, Guillaume; Schulthoff, Saskia; Hickmann, Volker; Moulin, Emilie; Herrmann, Jennifer; Mueller, Rolf; Fuerstner, Alois
Chemistry - A European Journal, 2009 , vol. 15, # 38 p. 9697 - 9706
反应条件
potassium hydroxide; hydrogen bromide 1.) AcOH, 1h; 2.) 120 deg C; Yield given. Multistep reaction;
参考文献
MacMillan, John B.; Molinski, Tadeusz F.
Journal of the American Chemical Society, 2004 , vol. 126, # 32 p. 9944 - 9945
反应条件
dihydrogen peroxide; [(S,S-(C6H5)2PCH(CH3)CH(CH3)P(C6H5)2)Pt(pentafluorophenyl)(OH2)]CF3SO3) in dichloromethane T=-10°C; 24 h; Title compound not separated from byproducts;
参考文献
Kubo, Takafumi; Peters, Matthew W.; Meinhold, Peter; Arnold, Frances H.
Chemistry - A European Journal, 2006 , vol. 12, # 4 p. 1216 - 1220
反应条件
water; acetic acid optical yield given as percent ee;
参考文献
Cui, Yubo; Tu, Wangyang; Floreancig, Paul E.
Tetrahedron, 2010 , vol. 66, # 26 p. 4867 - 4873
反应条件
1: 48.1 g / aq. HCl; NaNO2 / 15 h / -5 °C 2: 27.2 g / LiAlH4 / diethyl ether / -10 °C 3: 96 percent / KOH / 1 h / 25 °C View Scheme
参考文献
Plazinska, Anita; Pajak, Karolina; Rutkowska, Ewelina; Jimenez, Lucita; Kozocas, Joseph; Koolpe, Gary; Tanga, Mary; Toll, Lawrence; Wainer, Irving W.; Jozwiak, Krzysztof
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 234 - 246
反应条件
1: 27.2 g / LiAlH4 / diethyl ether / -10 °C 2: 96 percent / KOH / 1 h / 25 °C View Scheme
参考文献
Plazinska, Anita; Pajak, Karolina; Rutkowska, Ewelina; Jimenez, Lucita; Kozocas, Joseph; Koolpe, Gary; Tanga, Mary; Toll, Lawrence; Wainer, Irving W.; Jozwiak, Krzysztof
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 234 - 246
反应条件
1: 82 percent / 1N H2SO4, NaNO2 / H2O / 1 h / 0 - 5 °C 2: 66 percent / LAH / diethyl ether / 1.) 0 deg C, then 3 h rt. 3: 1.) HBr; 2.) 50percent aq. KOH / 1.) AcOH, 1h; 2.) 120 deg C View Scheme
参考文献
Mori, Kenji; Takaishi, Hideo
Tetrahedron, 1989 , vol. 45, # 6 p. 1639 - 1646
反应条件
1: 66 percent / LAH / diethyl ether / 1.) 0 deg C, then 3 h rt. 2: 1.) HBr; 2.) 50percent aq. KOH / 1.) AcOH, 1h; 2.) 120 deg C View Scheme
参考文献
Mori, Kenji; Takaishi, Hideo
Tetrahedron, 1989 , vol. 45, # 6 p. 1639 - 1646
反应条件
Jacobsen hydrolytic kinetic resolution; Resolution of racemate;
参考文献
Florence, Gordon J.; Cadou, Romain F.
Tetrahedron Letters, 2010 , vol. 51, # 44 p. 5761 - 5763
