tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tert-butyl alcohol T=100°C;

1: sodium hydride / N,N-dimethyl acetamide / 0 °C 2: tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl / tert-butyl alcohol / 100 °C View Scheme

1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 50 °C 2: iron; acetic acid / 50 °C 3: sodium hydride / N,N-dimethyl acetamide / 0 °C 4: tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl / tert-butyl alcohol / 100 °C View Scheme