N-(2-氟吡啶-4-羰基)-l-脯氨酸合成路线 （共 4 条）
反应条件
sodium hydroxide; sodium hydrogencarbonate in acetone 1.) 0 deg C, 2 h, 2.) RT, 1 h;
参考文献
Anderson, Wayne K.; Dean, Dennis C.; Endo, Toshiyasu
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1667 - 1675
反应条件
1: 1.) NaNO2, 2.) 48percent aq. HBF4 2: 36 percent / KMnO4 / H2O / 15 h / Heating 3: 93 percent / thionyl chloride / 25 h / Heating 4: 87 percent / 2 N aq. NaOH, 1 N aq. NaHCO3 / acetone / 1.) 0 deg C, 2 h, 2.) RT, 1 h View Scheme
参考文献
Anderson, Wayne K.; Dean, Dennis C.; Endo, Toshiyasu
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1667 - 1675
反应条件
1: 36 percent / KMnO4 / H2O / 15 h / Heating 2: 93 percent / thionyl chloride / 25 h / Heating 3: 87 percent / 2 N aq. NaOH, 1 N aq. NaHCO3 / acetone / 1.) 0 deg C, 2 h, 2.) RT, 1 h View Scheme
参考文献
Anderson, Wayne K.; Dean, Dennis C.; Endo, Toshiyasu
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1667 - 1675
反应条件
1: 93 percent / thionyl chloride / 25 h / Heating 2: 87 percent / 2 N aq. NaOH, 1 N aq. NaHCO3 / acetone / 1.) 0 deg C, 2 h, 2.) RT, 1 h View Scheme
参考文献
Anderson, Wayne K.; Dean, Dennis C.; Endo, Toshiyasu
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1667 - 1675
