4,4'-羰基二(苯甲酸甲基)酯合成路线 （共 8 条）
反应条件
1: 99.0 percent Chromat. / KCN, KI, KOH / palladium(II)acetate / hexamethylphosphoric acid triamide / 19 h / 95 °C
2: KOH / ethane-1,2-diol / 19 h / Heating
3: diethyl ether; methanol / Ambient temperature
View Scheme
参考文献
Kirste, Burkhard; Grimm, Michael; Kurreck, Harry
Journal of the American Chemical Society, 1989 , vol. 111, # 1 p. 108 - 114
反应条件
1: 11.8 percent / toluene / 48 h
2: CrO3, H2SO4 / acetic acid; acetic anhydride / 0.5 h / 10 °C
3: diethyl ether; methanol / Ambient temperature
View Scheme
参考文献
Kirste, Burkhard; Grimm, Michael; Kurreck, Harry
Journal of the American Chemical Society, 1989 , vol. 111, # 1 p. 108 - 114
反应条件
1: CrO3, H2SO4 / acetic acid; acetic anhydride / 0.5 h / 10 °C
2: diethyl ether; methanol / Ambient temperature
View Scheme
参考文献
Kirste, Burkhard; Grimm, Michael; Kurreck, Harry
Journal of the American Chemical Society, 1989 , vol. 111, # 1 p. 108 - 114
反应条件
tetracarbonylbis(μ-chloro)dirhodium(I); di-tert-butyl peroxide; triphenylphosphine in benzene
T=150°C; 12 h; Inert atmosphere; chemoselective reaction;
参考文献
Yang, Luo; Zeng, Tieqiang; Shuai, Qi; Guo, Xiangyu; Li, Chao-Jun
Chemical Communications, 2011 , vol. 47, # 7 p. 2161 - 2163
反应条件
1.1: i-PrMgCl / tetrahydrofuran / 0.67 h / -30 - -20 °C
1.2: 71 percent / tetrahydrofuran / -25 - 20 °C
2.1: 91 percent / PCC / CH2Cl2 / 20 °C
View Scheme
参考文献
Ulbrich, Holger K.; Luxenburger, Andreas; Prech, Philip; Eriksson, Einar E.; Soehnlein, Oliver; Rotzius, Pierre; Lindbom, Lennart; Dannhardt, Gerd
Journal of Medicinal Chemistry, 2006 , vol. 49, # 20 p. 5988 - 5999
反应条件
1.1: i-PrMgCl / tetrahydrofuran / 0.67 h / -30 - -20 °C
1.2: 71 percent / tetrahydrofuran / -25 - 20 °C
2.1: 91 percent / PCC / CH2Cl2 / 20 °C
View Scheme
参考文献
Ulbrich, Holger K.; Luxenburger, Andreas; Prech, Philip; Eriksson, Einar E.; Soehnlein, Oliver; Rotzius, Pierre; Lindbom, Lennart; Dannhardt, Gerd
Journal of Medicinal Chemistry, 2006 , vol. 49, # 20 p. 5988 - 5999
反应条件
in methanol; diethyl ether
Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Kirste, Burkhard; Grimm, Michael; Kurreck, Harry
Journal of the American Chemical Society, 1989 , vol. 111, # 1 p. 108 - 114
参考文献
Limpricht
Justus Liebigs Annalen der Chemie, 1900 , vol. 312, p. 98
