反应条件
1: H+ 2: 1) O3, 2) Me2S / 1) CH2Cl2, -78 deg C 3: 70 percent / n-BuLi / tetrahydrofuran / -78 deg C to r.t. 4: 98 percent / p-TsOH / methanol 5: 1) aq. NaOH, 2) 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate / 1) EtOH, 2) CH2Cl2 View Scheme
参考文献
Balasubramanian, N.; Brown, P. J.; Catt, J. D.; Han, W. T.; Parker, R. A.; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2038 - 2041
