Nagarajan, K.; Arya, V. P.; George, T.; Bhat, G.A.; Kulkarni, Y. S.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 10 p. 949 - 952
1: 6-chloro-nicotinic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole in DMF (N,N-dimethyl-formamide)
0.25 h;
2: pyrrolidine With N-ethyl-N,N-diisopropylamine in DMF (N,N-dimethyl-formamide)
T=20°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/101546 A1, 2004 ;
Location in patent: Page 28 ;
