7-氨基噻唑并[4,5-d]嘧啶-2(3h)-酮合成路线 （共 4 条）
反应条件
sodium hydroxide in water
参考文献
Brigham Young University
Patent: US4880784 A1, 1989 ;
反应条件
sodium hydroxide; dihydrogen peroxide in water 1.) RT, 1 h, 2.) 70 deg C, 1 h;
参考文献
Nagahara; Anderson; Kini; Dalley; Larson; Smee; Jin; Sharma; Jolley; Robins; Cottam
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 407 - 415
反应条件
1: 34 percent / 1.) 1 N, NaOH, sodium nitrite, 2.) aq. HCl, LiCl / 1.) 55 deg C, 2.) 45 deg C, 15 min 2: 88 percent / NaSH*xH2O / dimethylformamide / 1.) 0 deg C, overnight, 2.) RT, 2 h 3: 74 percent / 1 N NaOH, 30percent H2O2 / H2O / 1.) RT, 1 h, 2.) 70 deg C, 1 h View Scheme
参考文献
Nagahara; Anderson; Kini; Dalley; Larson; Smee; Jin; Sharma; Jolley; Robins; Cottam
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 407 - 415
反应条件
1: 88 percent / NaSH*xH2O / dimethylformamide / 1.) 0 deg C, overnight, 2.) RT, 2 h 2: 74 percent / 1 N NaOH, 30percent H2O2 / H2O / 1.) RT, 1 h, 2.) 70 deg C, 1 h View Scheme
参考文献
Nagahara; Anderson; Kini; Dalley; Larson; Smee; Jin; Sharma; Jolley; Robins; Cottam
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 407 - 415
