(S)-2-(5-碘-1H-咪唑-2-基)吡咯烷-1-羧酸叔丁酯合成路线 （共 5 条）
反应条件
water; sodium sulfite in ethanol 17 h; Reflux;
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; TAN, Yumei; LUO, Huichao
Patent: WO2014/19344 A1, 2014 ;
Location in patent: Paragraph 00355 ;
反应条件
1: With iodine; sodium hydroxide in chloroform; water T=20°C; 15 h; 2: With sodium sulfite in ethanol; water 40 h; Reflux;
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; TAN, Yumei; LUO, Huichao
Patent: WO2014/19344 A1, 2014 ;
反应条件
1.1: ammonia / water; methanol / 10 °C 2.1: sodium hydroxide; iodine / chloroform; water / 15 h / 20 °C 2.2: 40 h / Reflux View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; TAN, Yumei; LUO, Huichao
Patent: WO2014/19344 A1, 2014 ;
反应条件
1.1: sodium hydrogencarbonate; sodium hypochlorite; sodium bromide; chlorine; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / dichloromethane / 1 h / 0 °C 2.1: ammonia / water; methanol / 10 °C 3.1: sodium hydroxide; iodine / chloroform; water / 15 h / 20 °C 3.2: 40 h / Reflux View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; TAN, Yumei; LUO, Huichao
Patent: WO2014/19344 A1, 2014 ;
反应条件
1.1: dimethylsulfide borane complex / tetrahydrofuran / 18 h / 0 - 10 °C 1.2: 0 °C 2.1: sodium hydrogencarbonate; sodium hypochlorite; sodium bromide; chlorine; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / dichloromethane / 1 h / 0 °C 3.1: ammonia / water; methanol / 10 °C 4.1: sodium hydroxide; iodine / chloroform; water / 15 h / 20 °C 4.2: 40 h / Reflux View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; TAN, Yumei; LUO, Huichao
Patent: WO2014/19344 A1, 2014 ;
