1: N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-amine With sodium tris(acetoxy)borohydride in tetrahydrofuran T=20 - 25°C; 1 h; 2: With water; sodium hydroxide in tetrahydrofuran 3: toluene-4-sulfonic acid in tetrahydrofuran 3 h;

1: With methanol; sodium tetrahydroborate in tetrahydrofuran T=0 - 15°C; 2: With water in tetrahydrofuran

Multi-step reaction with 3 steps 1: acetic acid / xylene / 10 h / Reflux2: triethylamine / palladium 10 on activated carbon / ethylene glycol dimethyl ether; methanol / 15 h / 45 - 50 °C / Inert atmosphere3: triethylamine / methanol / 12 h / Reflux