1: acetic acid / xylene / 10 h / Reflux 2: triethylamine / palladium 10 on activated carbon / ethylene glycol dimethyl ether; methanol / 15 h / 45 - 50 °C / Inert atmosphere 3: triethylamine / methanol / 12 h / Reflux 4: sodium tetrahydroborate / tetrahydrofuran; methanol / 4 h / 10 - 15 °C 5: methanol / 3 h / 25 - 65 °C View Scheme

1: acetic acid / xylene / 10 h / Reflux 2: triethylamine / palladium 10 on activated carbon / ethylene glycol dimethyl ether; methanol / 15 h / 45 - 50 °C / Inert atmosphere View Scheme

1: With acetic acid in xylene 10 h; Reflux; 2: With ammonia in water; isopropyl alcohol T=20°C; pH=~ 10;

1: acetic acid / xylene / 10 h / Reflux 2: triethylamine / palladium 10 on activated carbon / ethylene glycol dimethyl ether; methanol / 15 h / 45 - 50 °C / Inert atmosphere 3: triethylamine / methanol / 12 h / Reflux 4: sodium tetrahydroborate / tetrahydrofuran; methanol / 4 h / 10 - 15 °C View Scheme

Multi-step reaction with 3 steps 1: acetic acid / xylene / 10 h / Reflux2: triethylamine / palladium 10 on activated carbon / ethylene glycol dimethyl ether; methanol / 15 h / 45 - 50 °C / Inert atmosphere3: triethylamine / methanol / 12 h / Reflux