lithium iodide in N,N-dimethyl-formamide 5 h; Heating;

lithium iodide demethylation;

Multi-step reaction with 6 steps 1: LDA / tetrahydrofuran; hexane / Ambient temperature2: diethyl ether3: 75 percent / NaOMe / methanol / 18 h / Heating4: 82 percent / air / ethanol; aq. NaOH / 24 h / Ambient temperature5: 0.41 g / 15percent HClO4 / 8 h / Heating6: 79 percent / trifluoroacetic anhydride / tetrahydrofuran / 12 h / Ambient temperature  

Multi-step reaction with 3 steps 1: 82 percent / air / ethanol; aq. NaOH / 24 h / Ambient temperature2: 0.41 g / 15percent HClO4 / 8 h / Heating3: 79 percent / trifluoroacetic anhydride / tetrahydrofuran / 12 h / Ambient temperature  

Multi-step reaction with 2 steps 1: 0.41 g / 15percent HClO4 / 8 h / Heating2: 79 percent / trifluoroacetic anhydride / tetrahydrofuran / 12 h / Ambient temperature  

Multi-step reaction with 4 steps 1: 75 percent / NaOMe / methanol / 18 h / Heating2: 82 percent / air / ethanol; aq. NaOH / 24 h / Ambient temperature3: 0.41 g / 15percent HClO4 / 8 h / Heating4: 79 percent / trifluoroacetic anhydride / tetrahydrofuran / 12 h / Ambient temperature