4,4-二氟环己基甲酸合成路线

参考文献

TOLERO PHARMACEUTICALS, INC.; XU, Yong; BRENNING, Benjamin, Gary; KULTGEN, Steven, G.; LIU, Xiaohui; SAUNDERS, Michael; HO, Koc-Kan
Patent: WO2013/13188 A1, 2013 ;
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WO 2013/013188 A1

17159-79-4对环己酮甲酸乙酯

122665-97-84,4-二氟环己基甲酸

参考文献

Tetrahedron Letters, , vol. 46, # 30 p. 5005 - 5007

122665-97-84,4-二氟环己基甲酸

810659-05-34，4-二氟环己基乙胺

参考文献

TOLERO PHARMACEUTICALS, INC.; XU, Yong; BRENNING, Benjamin, Gary; KULTGEN, Steven, G.; LIU, Xiaohui; SAUNDERS, Michael; HO, Koc-Kan
Patent: WO2013/13188 A1, 2013 ;
WO 2013/013188 A1

122665-97-84,4-二氟环己基甲酸+

376348-71-9(1S)-3-[3-(3-异丙基-5-甲基-4H-1,2,4-三唑-4-基)-外-8-氮杂双环[3.2.1]辛-8-基]-1-苯基-1-丙胺

376348-65-1马拉维若

参考文献

Price, David A.; Gayton, Simon; Selby, Matthew D.; Ahman, Jens; Haycock-Lewandowski, Sarah; Stammen, Blanda L.; Warren, Andrew
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122665-97-84,4-二氟环己基甲酸

22419-35-84,4-二氟环己醇

参考文献

BOEHRINGER INGELHEIM INTERNATIONAL GMBH; LEHMANN-LINTZ, Thorsten; HECKEL, Armin; KLEY, Joerg; LANGKOPF, Elke; REDEMANN, Norbert; SAUER, Achim; THOMAS, Leo; WIEDENMAYER, Dieter; AUSTEN, Matthias; DANILEWICZ, John; SCHNEIDER, Martin; SCHREITER, Kay; BLACK, Phillip; BLACKABY, Wesley; LINNEY, Ian
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WO 2011/104334 A1

122665-97-84,4-二氟环己基甲酸+

178312-47-5乙基-4,4-二氟环己烷羧酸盐

178312-48-64,4-二氟-环己烷甲醇

参考文献

Pfizer Inc
Patent: US6262075 B1, 2001 ;

122665-97-84,4-二氟环己基甲酸+

67-56-1甲醇

121629-14-94，4-二氟环己基甲酸甲酯

参考文献

WO2012/25857 A1, ;

Page/Page column 44-45 ;
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122665-97-84,4-二氟环己基甲酸

927209-98-14，4-二氟环己基甲酰胺

参考文献

TOLERO PHARMACEUTICALS, INC.; XU, Yong; BRENNING, Benjamin, Gary; KULTGEN, Steven, G.; LIU, Xiaohui; SAUNDERS, Michael; HO, Koc-Kan
Patent: WO2013/13188 A1, 2013 ;
Location in patent: Paragraph 00315; 00316 ;
WO 2013/013188 A1

122665-97-84,4-二氟环己基甲酸+

82769-76-4(S)-3-氨基-3-苯基丙醇

376348-77-54,4-二氟-N-((1S)-3-羟基-1-苯基丙基)环己烷甲酰胺

参考文献

ASTRAZENECA AB
Patent: WO2006/1752 A1, 2006 ;
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WO 2006/001752 A1

122665-97-84,4-二氟环己基甲酸

376348-75-34,4-二氟环己烷羰酰氯

参考文献

Haycock-Lewandowski, Sarah J.; Wilder, Alexander; Ahman, Jens
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