4-氯-3-甲氧基-2-甲基吡啶 N-氧化物合成路线 （共 11 条）
反应条件
dihydrogen peroxide; acetic acid T=90°C; 24 h;
参考文献
Maharvi, Ghulam M.; Bharucha, Adil E.; Fauq, Abdul H.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2808 - 2811
反应条件
1: 96 percent / POCl3 / 18 h / 90 °C 2: 90 percent / 30percent aq. H2O2, AcOH / 24 h / 90 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 6 p. 1049 - 1057
反应条件
in chloroform; acetic acid
反应条件
in methanol T=40°C; 16 h;
参考文献
Maharvi, Ghulam M.; Bharucha, Adil E.; Fauq, Abdul H.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2808 - 2811
反应条件
sodium methylate 18 h;
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
反应条件
1: 91 percent / NaOMe / 18 h 2: 2 h / 90 °C 3: 2 N aq. NaOH / 2 h / 80 °C 4: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C View Scheme
参考文献
Sharada; Satyanarayana Reddy; Sammaiah; Sumalatha
Asian Journal of Chemistry, 2013 , vol. 25, # 14 p. 7959 - 7966
反应条件
1: 91 percent / NaOMe / 18 h 2: 2 h / 90 °C 3: 2 N aq. NaOH / 2 h / 80 °C View Scheme
参考文献
Maharvi, Ghulam M.; Bharucha, Adil E.; Fauq, Abdul H.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2808 - 2811
反应条件
1: 91 percent / NaOMe / 18 h 2: 2 h / 90 °C 3: 2 N aq. NaOH / 2 h / 80 °C 4: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 5: 2 N aq. NaOH / ethanol / 2 h / 50 °C View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
反应条件
1: 91 percent / NaOMe / 18 h 2: 2 h / 90 °C 3: 2 N aq. NaOH / 2 h / 80 °C 4: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 5: 2 N aq. NaOH / ethanol / 2 h / 50 °C 6: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
反应条件
1: With acetic anhydride T=90°C; 0.383333 h; 2: With potassium hydroxide in methanol; water T=0 - 20°C; 0.5 h;
参考文献
Nagasawa, Masaaki; Nishioka, Hiroyasu; Asami, Kazuyasu; Miura, Naoyoshi; Shinozaki, Yutaka; Morita, Hitoshi
Patent: US2003/236411 A1, 2003 ;
Location in patent: Page 4 ;
