1: 77.4 percent / NEt3, dicyclohexylcarbodiimide (DCC) / dimethylformamide; CH2Cl2 / 1.) -20 deg C, overnight, 2.) RT, 4 h 2: ammonium formate, Pd(OAc)2 / 10percent Pd/C / ethyl acetate; methanol / 6 h / Ambient temperature 3: dicyclohexylcarbodiimide (DCC) / ethyl acetate / 1.) -20 deg C, overnight, 2.) RT, 4 h 4: ammonium formate, Pd(OAc)2 / 10percent Pd/C / ethanol; dimethylformamide / 7 h / Ambient temperature 5: dicyclohexylcarbodiimide (DCC) / ethyl acetate; dimethylformamide / 1.) -5 deg C, overnight, 2.) RT, 4 h 6: ammonium formate, Pd(OAc)2 / 10percent Pd/C / methanol; dimethylformamide / 7 h / Ambient temperature 7: dicyclohexylcarbodiimide (DCC) / ethyl acetate; dimethylformamide / 1.) -5 deg C, overnight, 2.) RT, 4 h 8: 71 percent / anisole, TFA / CH2Cl2 View Scheme

With  triethylamine; dicyclohexyl-carbodiimide in  dichloromethane; N,N-dimethyl-formamide  1.) -20 deg C, overnight, 2.) RT, 4 h;   

Multi-step reaction with 3 steps 1: 77.4 percent / NEt3, dicyclohexylcarbodiimide (DCC) / dimethylformamide; CH2Cl2 / 1.) -20 deg C, overnight, 2.) RT, 4 h2: ammonium formate, Pd(OAc)2 / 10percent Pd/C / ethyl acetate; methanol / 6 h / Ambient temperature3: dicyclohexylcarbodiimide (DCC) / ethyl acetate / 1.) -20 deg C, overnight, 2.) RT, 4 h  

Multi-step reaction with 5 steps 1: 77.4 percent / NEt3, dicyclohexylcarbodiimide (DCC) / dimethylformamide; CH2Cl2 / 1.) -20 deg C, overnight, 2.) RT, 4 h2: ammonium formate, Pd(OAc)2 / 10percent Pd/C / ethyl acetate; methanol / 6 h / Ambient temperature3: dicyclohexylcarbodiimide (DCC) / ethyl acetate / 1.) -20 deg C, overnight, 2.) RT, 4 h4: ammonium formate, Pd(OAc)2 / 10percent Pd/C / ethanol; dimethylformamide / 7 h / Ambient temperature5: dicyclohexylcarbodiimide (DCC) / ethyl acetate; dimethylformamide / 1.) -5 deg C, overnight, 2.) RT, 4 h  

Multi-step reaction with 7 steps 1: 77.4 percent / NEt3, dicyclohexylcarbodiimide (DCC) / dimethylformamide; CH2Cl2 / 1.) -20 deg C, overnight, 2.) RT, 4 h2: ammonium formate, Pd(OAc)2 / 10percent Pd/C / ethyl acetate; methanol / 6 h / Ambient temperature3: dicyclohexylcarbodiimide (DCC) / ethyl acetate / 1.) -20 deg C, overnight, 2.) RT, 4 h4: ammonium formate, Pd(OAc)2 / 10percent Pd/C / ethanol; dimethylformamide / 7 h / Ambient temperature5: dicyclohexylcarbodiimide (DCC) / ethyl acetate; dimethylformamide / 1.) -5 deg C, overnight, 2.) RT, 4 h6: ammonium formate, Pd(OAc)2 / 10percent Pd/C / methanol; dimethylformamide / 7 h / Ambient temperature7: dicyclohexylcarbodiimide (DCC) / ethyl acetate; dimethylformamide / 1.) -5 deg C, overnight, 2.) RT, 4 h