P-[[4-(4-氟苯基)-6-(1-甲基乙基)-2-[甲基(甲基磺酰基)氨基]-5-嘧啶基]甲基]膦酸二甲酯合成路线 （共 3 条）
反应条件
1: dimethyl [4-(4-fluorophenyl)-6-isopropyl-2-[methyl (methylsulfonyl) amino]pyrimidine-5-ylmethyl]phosphonate With sodium hexamethyldisilazane in tetrahydrofuran T=-78°C; 0.333333 h; Inert atmosphere; 2: tert-butyl 3,5-dideoxy-2,4-O-(1-methylethylidene)-L-erythro-hexuronate in tetrahydrofuran T=-35 - 0°C; 21 h; Product distribution / selectivity;
参考文献
EP2351762 A1, ;
Page/Page column 11 ;
反应条件
in toluene
T=20°C; 18 h; Inert atmosphereReflux;
参考文献
Kaneka Corporation
Patent: EP2351762 A1, 2011 ;
Location in patent: Page/Page column 10 ;
反应条件
1: phosphorus tribromide / toluene; acetonitrile / 1 h / 10 - 20 °C / Inert atmosphere
2: toluene / 18 h / 20 °C / Inert atmosphere; Reflux
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参考文献
Kaneka Corporation
Patent: EP2351762 A1, 2011 ;
