4-氨基-1-(2-脱氧-2,2-二氟呋喃戊糖基)-2(1H)-嘧啶酮盐酸盐(1:1)合成路线 （共 2 条）
反应条件
hydrogenchloride in water; isopropyl alcohol T=-4 - 60°C; 6.5 h;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2007/117760 A2, 2007 ;
Location in patent: Page/Page column 21 ;
反应条件
1: 4-acetylamino-1,2-dihydro-2-pyrimidone With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane in 1,2-dichloro-ethane 3 h; Heating / reflux; 2: 3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-D-ribofuranosyl mesylate With trimethylsilyl trifluoromethanesulfonate in 1,2-dichloro-ethane T=20 - 75°C; 14 - 16 h; Heating / reflux; 3: With hydrogenchloride in water; 1,2-dichloro-ethane
参考文献
POLTURI, Ramesh, Babu; VENKATA, Subramanian, Hariharakrishnan; BETINI, Ramesh
Patent: WO2005/95430 A1, 2005 ;
Location in patent: Page/Page column 18-20 ;
