hydrogenchloride in water; acetone T=20°C; 2 h; Product distribution / selectivity;

1: 1-bromo-2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-dibenzoate With triethylamine in tetrahydrofuran T=0 - 5°C; 2: (Ac)C(TMS)2 With trimethylsilyl trifluoromethanesulfonate in dichloromethane T=0 - 5°C; 3: in methanol T=40°C;

hydrogenchloride in water; isopropyl alcohol T=-4 - 60°C; 6.5 h;

sodium carbonate in methanol T=24°C; Hydrolysis; 4 h;

1: 4-acetylamino-1,2-dihydro-2-pyrimidone With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane in 1,2-dichloro-ethane 3 h; Heating / reflux; 2: 3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-D-ribofuranosyl mesylate With trimethylsilyl trifluoromethanesulfonate in 1,2-dichloro-ethane T=20 - 75°C; 14 - 16 h; Heating / reflux; 3: With hydrogenchloride in water; 1,2-dichloro-ethane

hydrogenchloride in 1,4-dioxane; water T=10 - 68°C; 1.5 h; Product distribution / selectivity;

in water; isopropyl alcohol T=25°C; 2 h; Resolution of anomeric mixture; Purification / work up;

1: pyridine / 15 h / 25 °C 2: acetic acid / water / 14 h / |Reflux View Scheme

potassium carbonate in ethanol; dichloromethane T=20°C;

1: pyridine / 15 h / 25 °C 2: acetic acid / water / 14 h / |Reflux 3: ammonia / methanol / 15 h / 20 °C View Scheme