5,5'-亚甲基二水杨酸合成路线 （共 16 条）
反应条件
760 torr; hydrogen; palladium on activated charcoal in ethanol; triethylamine 48 h; Ambient temperature;
参考文献
Cushman, Mark; Kanamathareddy, Suseela
Tetrahedron, 1990 , vol. 46, # 5 p. 1491 - 1498
反应条件
sulfuric acid 10 h; Reflux;
参考文献
Sanjeeva Reddy, Cherkupally; Raghu, Mekala
Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 12 p. 1732 - 1734
反应条件
1: 96 percent / H2SO4 / methanol; H2O / 1.)0 deg C, 1h 2.) r. t., 24h 2: 92 percent / H2, 760 torr / Pd/C (10percent) / ethanol; triethylamine / 48 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 46, # 5 p. 1491 - 1498
反应条件
sodium hydroxide in 1,4-dioxane T=80°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 10 p. 2760 - 2764
反应条件
potassium carbonate T=165 - 170°C; P=77228.3 Torr;
参考文献
Journal of Applied Chemistry, , vol. 3, p. 486,493
反应条件
1: H2SO4; acetic acid / 95 °C 2: aq. NaOH / dioxane / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 10 p. 2760 - 2764
参考文献
Archiv der Pharmazie (Weinheim, Germany), , vol. 245, p. 45
DE49970 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 2, p. 50
反应条件
sulfuric acid; sodium nitrite T=20°C; 18 h; Overall yield = 60percent; Overall yield = 0.6 g;
参考文献
AURIN BIOTECH INC.; MCGEER, Patrick; LEE, Moonhee; GUO, Jian-Ping; SCHWAB, Claudia
Patent: WO2014/9779 A1, 2014 ;
Location in patent: Paragraph 3 ;
反应条件
sulfuric acid; sodium nitrite
参考文献
Smith; Sager; Siewers
Analytical Chemistry, 1949 , vol. 21, p. 1334,1337
Full Text Show Details
Holaday
Journal of the American Chemical Society, 1940 , vol. 62, p. 989
参考文献
Caro
Chemische Berichte, 1892 , vol. 25, p. 947
