6-溴-2-苯基-(4H)-4-苯并吡喃酮合成路线 （共 34 条）
反应条件
piperidine; anhydrous iron chloride in toluene 7 h; Reflux;
参考文献
Tetrahedron Letters, , vol. 52, # 43 p. 5610 - 5612
反应条件
iodine T=100 - 110°C; 2.5 h; Neat (no solvent);
参考文献
Tetrahedron Letters, , vol. 53, # 18 p. 2355 - 2359
反应条件
sulfuric acid; iodine in dimethyl sulfoxide T=100°C; 0.5 h;
参考文献
Journal of Pharmacy and Pharmacology, , vol. 59, # 12 p. 1697 - 1701
反应条件
copper dichloride in ethanol 0.0833333 h; microwave irradiation;
参考文献
Tetrahedron Letters, , vol. 46, # 37 p. 6315 - 6317
反应条件
copper(l) iodide; oxygen T=50°C; oxa-Michael-oxidation; P=760.051 Torr; 48 h; Ionic liquid;
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 20 p. 6930 - 6933
反应条件
1: 5'-bromo-2'-hydroxyacetophenone With lithium hexamethyldisilazane in tetrahydrofuran T=-78 - -20°C; 2.5 h; 2: benzoyl chloride in tetrahydrofuran T=-78 - 20°C; 3 h; 3: With sulfuric acid; acetic acid in tetrahydrofuran T=120°C; 0.0833333 h;
参考文献
Chemical Communications, , # 46 p. 4814 - 4816
反应条件
iodine in dimethyl sulfoxide Inert atmosphere;
参考文献
Journal of Organometallic Chemistry, , vol. 734, p. 78 - 85
反应条件
lithium tert-butylate in N,N-dimethyl-formamide T=20 - 60°C; 2 h; regioselective reaction;
参考文献
European Journal of Organic Chemistry, , # 11 p. 2080 - 2083
反应条件
1: With iron(III) trifluoromethanesulfonate; palladium diacetate; 2,2,2-trimethylacetic acid T=60°C; under air; 2: With KNO2; 2,3-dicyano-5,6-dichloro-p-benzoquinone
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 36 p. 7305 - 7312
反应条件
1.1: potassium hydroxide; chloroform / water / 15 h / 60 °C 2.1: n-butyllithium / tetrahydrofuran / 6 h / -78 - -40 °C / |Inert atmosphere 2.2: 2 h / -78 °C / |Inert atmosphere 3.1: lithium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 - 60 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 11 p. 2080 - 2083
