N-(叔丁氧基羰基)甘氨酸-N′-甲氧基-N′-甲酰胺合成路线 （共 22 条）
反应条件
1: 3-bromo-furan With n-butyllithium in tetrahydrofuran; diethyl ether; hexane
T=-78°C; 0.666667 h; Inert atmosphere;
2: N-(tert-butoxycarbonyl)glycine N'-methoxy-N'-methylamide in tetrahydrofuran; diethyl ether; hexane
T=-78 - 20°C; 18 h; Inert atmosphere;
参考文献
GREEN CROSS CORPORATION; LEE, Jinhwa; KIM, Jeongmin; LEE, Suk Ho; LEE, Junwon; SONG, Kwang-Seop; PARK, Eun-Jung; KIM, Min Ju; SEO, Hee Jeong; LEE, Sung-Han; SON, Eun Jung; KIM, Jong Yup; KANG, Suk Youn; KONG, Younggyu
Patent: WO2011/159067 A2, 2011 ;
Location in patent: Page/Page column 59 ;
WO 2011/159067 A2
反应条件
1: 3-bromo-pyridine With isopropylmagnesium chloride in tetrahydrofuran
T=20°C; 1 h;
2: N-(tert-butoxycarbonyl)glycine N'-methoxy-N'-methylamide in tetrahydrofuran
T=-15 - 20°C;
参考文献
ASTRAZENECA AB
Patent: WO2005/61510 A1, 2005 ;
Location in patent: Page/Page column 24 ;
WO 2005/061510 A1
