N-Boc-反式-4-氨基-L-脯氨酸甲酯合成路线 （共 15 条）
反应条件
10 palladium on activated carbon; hydrogen in methanol T=20°C; P=760.051 Torr; 6 h;
参考文献
Torino, Domenica; Mollica, Adriano; Pinnen, Francesco; Feliciani, Federica; Spisani, Susanna; Lucente, Gino
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 251 - 259
反应条件
water; triphenylphosphine in tetrahydrofuran 6 h; Reflux;
参考文献
US2008/306086 A1, ;
Page/Page column 11-12; 28 ;
US 20080306086 A1
反应条件
1: 56.2 g / triethylamine / CH2Cl2 / 3 h / 0 - 5 °C 2: 88.7 percent / dimethylsulfoxide / 90 °C 3: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C 4: 100 percent / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 5: 90.8 percent / sodium azide / dimethylsulfoxide / 90 °C 6: H2 / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 5 p. 1399 - 1415
反应条件
1: NaN3 2: H2 / Pd/BaSO4 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 10 p. 2441 - 2445
反应条件
1: thionyl chloride / 6 h / Heating 2: 53.4 g / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 3: 56.2 g / triethylamine / CH2Cl2 / 3 h / 0 - 5 °C 4: 88.7 percent / dimethylsulfoxide / 90 °C 5: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C 6: 100 percent / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 7: 90.8 percent / sodium azide / dimethylsulfoxide / 90 °C 8: H2 / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 5 p. 1399 - 1415
反应条件
1: 53.4 g / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 2: 56.2 g / triethylamine / CH2Cl2 / 3 h / 0 - 5 °C 3: 88.7 percent / dimethylsulfoxide / 90 °C 4: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C 5: 100 percent / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 6: 90.8 percent / sodium azide / dimethylsulfoxide / 90 °C 7: H2 / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 5 p. 1399 - 1415
反应条件
1: 53.4 g / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 2: 56.2 g / triethylamine / CH2Cl2 / 3 h / 0 - 5 °C 3: 88.7 percent / dimethylsulfoxide / 90 °C 4: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C 5: 100 percent / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 6: 90.8 percent / sodium azide / dimethylsulfoxide / 90 °C 7: H2 / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 5 p. 1399 - 1415
反应条件
1: 88.7 percent / dimethylsulfoxide / 90 °C 2: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C 3: 100 percent / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 4: 90.8 percent / sodium azide / dimethylsulfoxide / 90 °C 5: H2 / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 5 p. 1399 - 1415
反应条件
1: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C 2: 100 percent / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 3: 90.8 percent / sodium azide / dimethylsulfoxide / 90 °C 4: H2 / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 5 p. 1399 - 1415
反应条件
1: NaN3 / dimethylformamide / 5 h / 50 °C 2: H2 / Pd/C / methanol / 4 h / 1551.4 Torr View Scheme
参考文献
Tetrahedron, , vol. 52, # 47 p. 15017 - 15030
