1-(十二烷氧基)-4-乙炔基苯合成路线 （共 11 条）
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) Hagihara-Sonogashira coupling; 3 h;
参考文献
Weiss, Klaus; Beernink, Gunda; Doetz, Florian; Birkner, Alexander; Muellen, Klaus; Woell, Christof H.
Angewandte Chemie - International Edition, 1999 , vol. 38, # 24 p. 3748 - 3752
反应条件
1.1: 70 percent / CuI; PdCl2(PPh3)2; Et3N / 48 h / 20 °C 2.1: Zn; PPh3 / CH2Cl2 / 24 h / 20 °C 2.2: 95 percent / CH2Cl2 / 0 - 20 °C 3.1: 86 percent / LDA / tetrahydrofuran / 3 h / -78 - 0 °C View Scheme
参考文献
Armaroli, Nicola; Accorsi, Gianluca; Rio, Yannick; Ceroni, Paola; Vicinelli, Veronica; Welter, Richard; Gu, Tao; Saddik, Mohamed; Holler, Michel; Nierengarten, Jean-Francois
New Journal of Chemistry, 2004 , vol. 28, # 12 p. 1627 - 1637
反应条件
potassium fluoride; water in N,N-dimethyl-formamide
Hydrolysis; 3 h;
参考文献
Weiss, Klaus; Beernink, Gunda; Doetz, Florian; Birkner, Alexander; Muellen, Klaus; Woell, Christof H.
Angewandte Chemie - International Edition, 1999 , vol. 38, # 24 p. 3748 - 3752
反应条件
1: triphenylphosphine; triethylamine / bis(triphenylphosphine) palladium dichloride; copper(I) iodide / tetrahydrofuran / 2 h / Heating
2: KOH / toluene / Heating
View Scheme
参考文献
Yang; Tang; Gong; Wen
Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 2000 , vol. 348, p. 153 - 165
反应条件
1: KOH / ethanol; H2O
2: triphenylphosphine; triethylamine / bis(triphenylphosphine) palladium dichloride; copper(I) iodide / tetrahydrofuran / 2 h / Heating
3: KOH / toluene / Heating
View Scheme
参考文献
Yang; Tang; Gong; Wen
Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 2000 , vol. 348, p. 153 - 165
反应条件
1: 85 percent / K2CO3 / dimethylformamide / 3 h / Heating
2: 92 percent / CuI; PPh3; piperidine / trans-[Pd(PPh3)2Cl2] / 6 h
3: 98 percent / KF; H2O / dimethylformamide / 3 h
View Scheme
参考文献
Weiss, Klaus; Beernink, Gunda; Doetz, Florian; Birkner, Alexander; Muellen, Klaus; Woell, Christof H.
Angewandte Chemie - International Edition, 1999 , vol. 38, # 24 p. 3748 - 3752
反应条件
1.1: PPh3; Zn / CH2Cl2 / 24 h / 20 °C
1.2: 80 percent / CH2Cl2 / 24 h
2.1: 90 percent / LDA / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Gehringer, Lionel; Bourgogne, Cyril; Guillon, Daniel; Donnio, Bertrand
Journal of the American Chemical Society, 2004 , vol. 126, # 12 p. 3856 - 3867
反应条件
1: copper(I)iodide, triphenylphosphine / dichlorobis(triphenylphosphine)palladium / triethylamine / 90 °C
2: sodium hydride / toluene; paraffin / 110 °C
View Scheme
参考文献
Seto; Shimojitosho; Imazaki; Matsubara; Takahashi
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 4 p. 1020 - 1025
反应条件
1: K2CO3 / butan-2-one / 24 h / 110 °C
2: PPh3 / CH2Cl2 / 6 h / cooling
3: n-BuLi / tetrahydrofuran / 5 h / -78 - 20 °C
View Scheme
参考文献
Kaafarani, Bilal R.; Wex, Brigitte; Wang, Fei; Catanescu, Otilia; Chien; Neckers, Douglas C.
Journal of Organic Chemistry, 2003 , vol. 68, # 13 p. 5377 - 5380
反应条件
1: POCl3, DMF / CH2Cl2 / 5 h / Heating
2: 0.2 M NaOH / dioxane / 24 h / Heating
View Scheme
参考文献
Kitamura, Tsugio; Lee, Chi Han; Taniguchi, Hiroshi; Matsumoto, Masaru; Sano, Youich
Journal of Organic Chemistry, 1994 , vol. 59, # 26 p. 8053 - 8057
