反应条件
1: potassium tert-butylate; copper(l) chloride; N-methoxyamine hydrochloride / N,N-dimethyl-formamide / 1 h / 15 - 20 °C
2: hydrogenchloride; potassium iodide; sodium nitrite / water / 20 °C / Cooling with ice
3: ethanol; SnCl2·2H2O / 0.5 h / 0 - 70 °C
4: 2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride / dimethyl sulfoxide / 16 h / 0 - 120 °C
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; ElexoPharm GmbH; HOYT, Scott, B.; PETRILLI, Whitney Lane; LONDON, Clare; XIONG, Yusheng; TAYLOR, Jerry Andrew; ALI, Amjad; LO, Michael; HENDERSON, Timothy, J.; HU, Qingzhong; HARTMANN, Rolf; YIN, Lina; HEIM, Ralf; BEY, Emmanuel; SAXENA, Rohit; SAMANTA, Swapan Kumar; KULKARNI, Bheemashankar, A.
Patent: WO2012/148808 A1, 2012 ;
WO 2012/148808 A1