3-氨基-4-氯三氟甲苯合成路线 （共 32 条）
反应条件
2: SnCl2 View Scheme
参考文献
Nagarajan, K.; Talwalker, P.K.; Kulkarni, C.L.; Venkateswarlu, A.; Prabhu, S.S.; Nayak, G.V.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1243 - 1257
反应条件
1: (i) NaNO2, H2SO4, (ii) aq. ZnCl2, (iii) /BRN= 3587243/, CuCN, aq. NaHCO3, PE
2: (i) Et2O, benzene, (ii) HCl, (iii) aq. H2SO4, toluene
3: aq. NH3, CuCl / dioxane / 140 °C
View Scheme
参考文献
Saucy,G.; Sternbach,L.H.
Helvetica Chimica Acta, 1962 , vol. 45, p. 2226 - 2241
反应条件
1: (i) NaNO2, aq. HCl, (ii) SO3, CuCl2, AcOH
2: aq. NH3
View Scheme
参考文献
Pirotte, Bernard; De Tullio, Pascal; Florence, Xavier; Goffin, Eric; Somers, Fabian; Boverie, Stephane; Lebrun, Philippe
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3247 - 3256
反应条件
N-chloro-succinimide
参考文献
THE DOW CHEMICAL COMPANY
Patent: EP142152 B1, 1991 ;
反应条件
palladium diacetate; potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in ethylene glycol dimethyl ether
T=20 - 80°C; 48 h;
参考文献
Weinrich, Melissa L.; Beck, Hilary P.
Tetrahedron Letters, 2009 , vol. 50, # 50 p. 6968 - 6972
反应条件
1: (i) NaNO2, H2SO4, (ii) aq. ZnCl2, (iii) /BRN= 3587243/, CuCN, aq. NaHCO3, PE
2: (i) Et2O, benzene, (ii) HCl, (iii) aq. H2SO4, toluene
View Scheme
参考文献
Saucy,G.; Sternbach,L.H.
Helvetica Chimica Acta, 1962 , vol. 45, p. 2226 - 2241
参考文献
Stauffer Chemical Company
Patent: US4469701 A1, 1984 ;
反应条件
1: Pd2(dba)3; NaO-t-Bu / dioxane / 45 °C
2: 87 percent / Pd(OAc)2; PCy3*HBF4; K2CO3 / N,N-dimethyl-acetamide / 130 °C
View Scheme
参考文献
Campeau, Louis-Charles; Thansandote, Praew; Fagnou, Keith
Organic Letters, 2005 , vol. 7, # 9 p. 1857 - 1860
参考文献
Porai-Koschiz et al.
Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1955 , vol. 28, p. 969,972
Chem.Abstr., 1956 , p. 4880
反应条件
potassium hydroxide in N-methyl-acetamide
参考文献
Imperial Chemical Industries Limited
Patent: US4128665 A1, 1978 ;
