反应条件
1.1: bromine; acetic acid / 1.5 h
2.1: copper; sodium hydroxide / water / Reflux
2.2: Reflux
3.1: sodium carbonate / acetone / 6 h / Reflux
4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C
5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C
6.1: sodium hydroxide / methanol / 3 h / 20 °C
7.1: potassium carbonate / acetone
8.1: trichlorophosphate / 3.5 h / 0 - 80 °C
View Scheme
参考文献
Huang, Guan-Jhong; Bhaskar Reddy, M. Vijaya; Kuo, Ping-Chung; Huang, Chieh-Hung; Shih, Hung-Cheng; Lee, E.-Jian; Yang, Mei-Lin; Leu, Yann-Lii; Wu, Tian-Shung
European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 371 - 378