4-氯-3-硝基三氟甲苯合成路线 （共 136 条）
反应条件
tri[2-(2-methoxyethoxy)ethyl]amine in chlorobenzene 4 h; Heating;
参考文献
Soula, Gerard
Journal of Organic Chemistry, 1985 , vol. 50, # 20 p. 3717 - 3721
反应条件
18-crown-6 ether; trichloroacetic acid methyl ester; potassium carbonate T=150°C; 2 h;
参考文献
Renga, James M.; Wang, Pen-Chung
Synthetic Communications, 1984 , vol. 14, # 1 p. 69 - 76
反应条件
1: aq. KOH 2: H2 / Raney-Ni / dioxane 3: 144 h / Heating 4: Py*HBr / 0.67 h / 200 °C View Scheme
参考文献
Fuhrer,H. et al.
Journal of Heterocyclic Chemistry, 1979 , vol. 16, p. 1121 - 1134
反应条件
in N,N-dimethyl-formamide T=75 - 80°C;
参考文献
D'Amico,J.J. et al.
Journal of Organic Chemistry, 1977 , vol. 42, p. 2896 - 2899
参考文献
Brown,C.; Hogg,D.R.
Journal of the Chemical Society [Section] B: Physical Organic, 1968 , p. 1315 - 1317
反应条件
sodium methylate in ethanol T=195°C;
参考文献
Fuhrer,H. et al.
Journal of Heterocyclic Chemistry, 1979 , vol. 16, p. 1121 - 1134
Full Text Show Details
Olmsted,M.P. et al.
Journal of Organic Chemistry, 1961 , vol. 26, p. 1901 - 1907
反应条件
1: triethylamine / N,N-dimethyl-formamide / 1 h / 100 °C 2: triethylamine; formic acid / palladium 10 on activated carbon / ethanol / 2 h / Inert atmosphere View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; SIMONEAU, Bruno; DEROY, Patrick; FADER, Lee; FAUCHER, Anne-Marie; GAGNON, Alexandre; GRAND-MAITRE, Chantal; KAWAI, Steven; LANDRY, Serge; MERCIER, Jean-Francois; RANCOURT, Jean
Patent: WO2011/100838 A1, 2011 ;
反应条件
bis(η3-allyl-μ-chloropalladium(II)); N,N,N',N'-tetra(diphenylphosphinomethyl)benzene-1,3-diamine; potassium carbonate in N,N-dimethyl acetamide T=130°C; Suzuki-Miyaura Coupling; 20 h; Inert atmosphereSchlenk technique; TimeConcentration;
参考文献
Wang, Kun; Wang, Wei; Luo, Heng; Zheng, Xueli; Fu, Haiyan; Chen, Hua; Li, Ruixiang
Catalysis Letters, 2013 , vol. 143, # 11 p. 1214 - 1219
反应条件
in dimethyl sulfoxide T=50°C; 2 h;
参考文献
WYETH
Patent: WO2008/60998 A1, 2008 ;
Location in patent: Page/Page column 120-122 ;
反应条件
1: ethanol 2: aqueous H2O2; acetic acid View Scheme
参考文献
Stacy et al.
Journal of Organic Chemistry, 1957 , vol. 22, p. 298,299, 301
