1: 57 percent / phosphorus trichloride / tetrahydrofuran / 0.5 h / Ambient temperature 2: 88 percent / sodium methoxide / methanol / 20 h / Heating 3: 67 percent / potassium permanganate, aq. 0.5 N sodium hydroxide / 0.5 h / 50 - 55 °C 4: 79 percent / aq. sodium hydroxide (1 N) / 2 h / 65 - 68 °C View Scheme

With  triethyl phosphite T=130°C; 1.33333 h;  Show Experimental Procedure  

Multi-step reaction with 2 steps 1: 57 percent / phosphorus trichloride / tetrahydrofuran / 0.5 h / Ambient temperature2: 88 percent / sodium methoxide / methanol / 20 h / Heating  

Multi-step reaction with 2 steps 1: 88 percent / methanol / 18 h / Heating2: 99 percent / aq.sodium hydroxide (1 N) / 2 h / Heating  

Multi-step reaction with 3 steps 1: 88 percent / methanol / 18 h / Heating2: 99 percent / aq.sodium hydroxide (1 N) / 2 h / Heating3: 89 percent / aq.sodium hydroxide (0.5 N), sodium dithionite / 0.25 h / Heating