1-苄基六氢氮杂卓-4-酮合成路线 （共 13 条）
反应条件
potassium carbonate in acetone T=20°C; 16 h;
参考文献
SEPRACOR INC.; CHYTIL, Milan; ENGEL, Sharon, R.; FANG, Qun, Kevin
Patent: WO2010/144571 A1, 2010 ;
Location in patent: Page/Page column 133-134 ;
WO 2010/144571 A1
反应条件
1: With potassium tert-butylate in xylene T=145°C; Inert atmosphere; 2: With hydrogenchloride in water; xylene T=0°C; 3: in xylene 2 h; Reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2011/195954 A1, 2011 ;
Location in patent: Page/Page column 106 ;
反应条件
1: With triethylamine in dichloromethane T=20°C; 0.5 h; 2: With sodium tris(acetoxy)borohydride in dichloromethane T=20°C;
参考文献
Gruenenthal GmbH
Patent: US2010/249095 A1, 2010 ;
Location in patent: Page/Page column 131 ;
US 20100249095 A1
反应条件
BaO in methanol T=-15°C;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1500643 A1, 2005 ;
Location in patent: Page 27; 47 ;
EP 1500643 A1
反应条件
1.1: ethanol / 15 h / 20 °C 2.1: potassium carbonate / acetonitrile / 12 h / 20 - 90 °C 3.1: potassium tert-butylate / xylene / 145 °C / Inert atmosphere 3.2: 0 °C / Reflux View Scheme
反应条件
1.1: potassium carbonate / acetonitrile / 12 h / 20 - 90 °C 2.1: potassium tert-butylate / xylene / 145 °C / Inert atmosphere 2.2: 0 °C / Reflux View Scheme
反应条件
1.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C / |Inert atmosphere 1.2: 0.5 h / -78 °C / |Inert atmosphere 1.3: |Inert atmosphere 2.1: sodium sulfate; silica gel / hexane; tetrahydrofuran; diethyl ether / 0.17 h / |Inert atmosphere View Scheme
参考文献
Chemistry - A European Journal, , vol. 18, # 38 p. 11889 - 11893
反应条件
1: water; hydrochloric acid / Behandeln des Reaktionsprodukts mit wss. Natronlauge 2: methanol; barium oxide View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 31, p. 418,420
反应条件
diethyl ether; di-isopropyl ether; sodium N-methylanilide Reagens 4: Styrol. Erhitzen des Reaktionsprodukts in Benzol mit wss. Schwefelsaeure.;
参考文献
Bulletin des Societes Chimiques Belges, , vol. 67, p. 256,265
反应条件
2: diethyl ether; sodium-compound of N-methyl-aniline; diisopropyl ether / Reagens 4: Styrol. Erhitzen des Reaktionsprodukts in Benzol mit wss. Schwefelsaeure. View Scheme
参考文献
Bulletin des Societes Chimiques Belges, , vol. 67, p. 256,265
