4-[双-(2-氯乙基)氨基]苯甲醛合成路线 （共 47 条）
反应条件
in ethanol
0.25 h; Heating;
参考文献
Azev, Yu. A.; Vereshchagina, N. N.; Pidemskii, E. L.; Goleneva, A. F.; Aleksandrova, G. A.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 5 p. 322 - 325
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 5 p. 573 - 576
反应条件
sodium iodide in butanone
T=65°C; 24 h;
参考文献
Morgan, M. Thomas; Bagchi, Pritha; Fahrni, Christoph J.
Journal of the American Chemical Society, 2011 , vol. 133, # 40 p. 15906 - 15909
反应条件
piperidine in 1,4-dioxane
Heating;
参考文献
Belogorodskii, V. V.; Myuller, N. R.; Filov, V. A.; Ivin, B. A.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 3 p. 163 - 167
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 3 p. 20 - 25
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere
1.2: 1.5 h / 20 °C / Inert atmosphere
2.1: palladium 10 on activated carbon; hydrogen / ethyl acetate / 1.5 h / 20 °C
3.1: hydrogenchloride / 4 h / 100 °C
View Scheme
参考文献
Khunnawutmanotham, Nisachon; Chimnoi, Nitirat; Champathong, Wattanachai; Lerdsirisuk, Pradit; Khotmor, Theeraphon; Techasakul, Supanna
Journal of Chemical Research, 2012 , vol. 36, # 6 p. 374 - 378
参考文献
Popp,F.D.
Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 627 - 629
反应条件
sodium tetrahydroborate
参考文献
Iwamoto,R.H. et al.
J. Med. Chem., 1963 , vol. 6, p. 43 - 46
参考文献
Chou et al.
Scientia PekingChem.Abstr., 1959 , vol. 14, p. 457
Scientia PekingChem.Abstr., 1960 , p. 7716
反应条件
1: NaBH4
2: aq. HCl
3: aq. H2O2 / acetic acid
View Scheme
参考文献
Iwamoto,R.H. et al.
J. Med. Chem., 1963 , vol. 6, p. 43 - 46
反应条件
5A molecular sieve in N,N-dimethyl-formamide
Ambient temperature;
参考文献
Bhat; Montero; Panzica; Wotring; Townsend
Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1165 - 1172
参考文献
Popp,F.D.
Journal of Organic Chemistry, 1961 , vol. 26, p. 3019 - 3020
