4-[(叔-丁基二甲基甲硅烷)氧代]苯甲醛合成路线 （共 42 条）
反应条件
1: 94 percent / i-Pr2NEt
2: 33 percent / aq. DDQ / toluene / 79 h / 80 °C
View Scheme
参考文献
Miki, Yasuyoshi; Hachiken, Hiroko; Kashima, Yoshimi; Sugimura, Wakiko; Yanase, Norihide
Heterocycles, 1998 , vol. 48, # 1 p. 1 - 4
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; bis(1,5-cyclooctadiene)nickel (0) in toluene
T=95°C; 2.8 h; Heatingother reagent, temperature; Product distribution;
参考文献
Mann, Grace; Hartwig, John F.
Journal of Organic Chemistry, 1997 , vol. 62, # 16 p. 5413 - 5418
反应条件
1: 1) n-BuLi / 1) THF, -76 deg C, 10 min, 2) THF, 1 h
2: 90 percent / diisopropylethyl amine / CH2Cl2 / 3.5 h / 23 °C
3: 92 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C
4: 97 percent / pyridine / a) 0 deg C, 15 min, b) 20 min
5: 98 percent / (n-Bu)4NF / tetrahydrofuran / 0.33 h / 23 °C
6: 87 percent / NaH / tetrahydrofuran / 2.5 h
7: 1) NaH, n-BuLi / 1) THF, 0 deg C, 10 min, 2) THF, 0 deg C, 1 h
8: 99 percent / CF3COOH / CHCl3 / 0.67 h / 23 °C
9: 98 percent / LiBr, DMSO / 0.67 h / 180 °C
View Scheme
参考文献
Angle, Steven R.; Louie, Michael S.
Journal of Organic Chemistry, 1991 , vol. 56, # 8 p. 2853 - 2866
反应条件
sodium tetrahydroborate; silica gel in dichloromethane
T=0°C; 0.0833333 h;
参考文献
Quiroz-Florentino, Hector; Hernandez-Benitez, R. Israel; Avina, Judit A.; Burgueno-Tapia, Eleuterio; Tamariz, Joaquin
Synthesis, 2011 , # 7 p. 1106 - 1112
反应条件
sodium tetrahydroborate in ethanol
参考文献
Ohio State University Research Foundation
Patent: US6117845 A1, 2000 ;
反应条件
1: BuLi / tetrahydrofuran / 3 h / -70 - 20 °C
2: MnO2 / CH2Cl2 / 20 °C
3: HF / acetonitrile / 20 °C
View Scheme
参考文献
Nussbaumer, Peter; Bilban, Melitta; Billich, Andreas
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 16 p. 2093 - 2095
反应条件
tetrafluoroboric acid
T=20°C; 0.0333333 h;
参考文献
Kamble, Vinod T.; Bandgar, Babasaheb P.; Joshi, Neeta S.; Jamode, Vasant S.
Synlett, 2006 , # 17 p. 2719 - 2722
反应条件
1: With titanocene(III) chloride in tetrahydrofuran
T=20°C; 17 h;
2: With sulfuric acid; water in tetrahydrofuran
参考文献
Mandal, Samir Kumar; Roy, Subhas Chandra
Tetrahedron, 2008 , vol. 64, # 49 p. 11050 - 11057
反应条件
1.1: sBuLi / tetrahydrofuran; cyclohexane; hexane / -78 °C
2.1: sBuLi; B(OMe)3 / tetrahydrofuran; cyclohexane; hexane / -78 - 20 °C
2.2: H2O2 / acetic acid / 20 °C
2.3: TFA / tetrahydrofuran; H2O / Heating
View Scheme
参考文献
Tahara, Naruki; Fukuda, Tsutomu; Iwao, Masatomo
Tetrahedron Letters, 2004 , vol. 45, # 26 p. 5117 - 5120
反应条件
1: BuLi / tetrahydrofuran / 3 h / -70 - 20 °C
2: MnO2 / CH2Cl2 / 20 °C
3: HF / acetonitrile / 20 °C
4: aluminium chloride / 20 °C
View Scheme
参考文献
Nussbaumer, Peter; Bilban, Melitta; Billich, Andreas
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 16 p. 2093 - 2095
