(r)-3-氨基-3-甲基-丙酸叔丁酯合成路线 （共 6 条）
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 89 percent / tetrahydrofuran; hexane / 3 h / -78 °C 2.1: 84 percent / H2; acetic acid / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 760.05 Torr View Scheme
参考文献
Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D.
Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 93 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.2: 89 percent / tetrahydrofuran; hexane / 3 h / -78 °C 3.1: 84 percent / H2; acetic acid / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 760.05 Torr View Scheme
参考文献
Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D.
Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566
反应条件
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C / Inert atmosphere 2.1: 20 wt. Pd(OH)2/C; hydrogen; acetic acid / methanol / 18 h / 3800.26 Torr View Scheme
参考文献
Davies, Stephen G.; Lee, James A.; Roberts, Paul M.; Thomson, James E.; Yin, Jingda
Tetrahedron, 2011 , vol. 67, # 34 p. 6382 - 6403
反应条件
perchloric acid T=20°C; 24 h;
参考文献
Li, Xiang-Guo; Laehitie, Maria; Kanerva, Liisa T.
Tetrahedron Asymmetry, 2008 , vol. 19, # 15 p. 1857 - 1861
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 15 h;
参考文献
Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D.
Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566
反应条件
potassium hydroxide; aluminium trichloride in diethyl ether; water
参考文献
Wehner, Volkmar; Blum, Horst; Rutten, Hartmut; Stilz, Hans Ulrich
Patent: US2003/73723 A1, 2003 ;
